Biology:Octamer transcription factor
Octamer transcription factors are a family of transcription factors which binds to the "ATTTGCAT" DNA sequence.[1] Their DNA-binding domain is a POU domain.
There are eight Octamer proteins in humans (Oct1–11),[2] which have been renamed according to the different classes of POU domain.[3] Octamer-3/4, also known as POU5F1, is one of the Yamanaka factors, which are critical for the maintenance and self-renewal of embryonic stem cells.[3] On the other hand, Oct-1 and Oct-2 are widely expressed in adult tissues.[3] Oct-7, 8 and 9, also known as "brain factors", are predominantly expressed in the central nervous system during embryonic development.[3] Oct-6 expression is confined to embryonic stem cells and the developing nervous system and skin, while Oct-11 is also involved in skin differentiation.[3]
Human Oct proteins
- Oct-1 - POU2F1
- Oct-2 - POU2F2
- Oct-3/4 – POU5F1
- Oct-6 – POU3F1
- Oct-7 – POU3F2
- Oct-8 – POU3F3
- Oct-9 – POU3F4
- Oct-11 – POU3F4
References
- ↑ "Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution". Proc. Natl. Acad. Sci. U.S.A. 87 (3): 1099–103. 1990. doi:10.1073/pnas.87.3.1099. PMID 1967834. Bibcode: 1990PNAS...87.1099P.
- ↑ Oct-5 and Oct-10 are not found in humans, while Oct-3 and Oct-4 were identified as the same protein.
- ↑ 3.0 3.1 3.2 3.3 3.4 Zhao, FQ (1 June 2013). "Octamer-binding transcription factors: genomics and functions.". Frontiers in Bioscience (Landmark Edition) 18 (3): 1051–71. doi:10.2741/4162. PMID 23747866.
External links
- Octamer+transcription+factors at the US National Library of Medicine Medical Subject Headings (MeSH)
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