Biology:PBX2
 Generic protein structure example |
Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.[1][2]
Function
This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.[2]
Interactions
PBX2 has been shown to interact with HOXA9.[3]
References
- ↑ "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3". Genomics 23 (2): 408–19. Sep 1994. doi:10.1006/geno.1994.1517. PMID 7835890.
- ↑ 2.0 2.1 "Entrez Gene: PBX2 pre-B-cell leukemia homeobox 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5089.
- ↑ "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology 19 (4): 3051–61. Apr 1999. doi:10.1128/mcb.19.4.3051. PMID 10082572.
Further reading
- "PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1". Molecular and Cellular Biology 11 (12): 6149–57. Dec 1991. doi:10.1128/mcb.11.12.6149. PMID 1682799.
- "The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein". Genomics 25 (3): 650–9. Feb 1995. doi:10.1016/0888-7543(95)80007-9. PMID 7759099.
- "Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation". Molecular and Cellular Biology 14 (6): 3938–48. Jun 1994. doi:10.1128/mcb.14.6.3938. PMID 7910944.
- "Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci". Genomics 35 (1): 101–8. Jul 1996. doi:10.1006/geno.1996.0328. PMID 8661110.
- "Prep1, a novel functional partner of Pbx proteins". The EMBO Journal 17 (5): 1423–33. Mar 1998. doi:10.1093/emboj/17.5.1423. PMID 9482739.
- "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology 19 (4): 3051–61. Apr 1999. doi:10.1128/MCB.19.4.3051. PMID 10082572.
- "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes". Experimental Hematology 29 (7): 856–63. Jul 2001. doi:10.1016/S0301-472X(01)00655-5. PMID 11438208.
- "A complex containing PBX2 contributes to activation of the proto-oncogene HOX11". Biochemical and Biophysical Research Communications 294 (1): 23–34. May 2002. doi:10.1016/S0006-291X(02)00426-6. PMID 12054735.
- "Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene". Blood 101 (12): 4748–56. Jun 2003. doi:10.1182/blood-2002-02-0380. PMID 12609849.
- "Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation". The Journal of Biological Chemistry 278 (40): 39235–41. Oct 2003. doi:10.1074/jbc.M304704200. PMID 12871956.
- "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Research 13 (12): 2621–36. Dec 2003. doi:10.1101/gr.1736803. PMID 14656967.
- "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–67. Jan 2004. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
External links
- PBX2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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