Biology:SOX13

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Transcription factor SOX-13 is a protein that in humans is encoded by the SOX13 gene.

Function

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12.

In melanocytic cells SOX13 gene expression may be regulated by MITF.

See also

• SOX genes

Further reading

• "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Current Opinion in Genetics & Development 12 (4): 441–6. Aug 2002. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890. 
• "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Developmental Cell 3 (2): 167–70. Aug 2002. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848. 
• "High expression of the HMG box factor sox-13 in arterial walls during embryonic development". Nucleic Acids Research 26 (2): 469–76. Jan 1998. doi:10.1093/nar/26.2.469. PMID 9421502. 
• "Genomic characterisation and fine mapping of the human SOX13 gene". Gene 250 (1–2): 181–9. May 2000. doi:10.1016/S0378-1119(00)00157-8. PMID 10854791. 
• "Sex-determining region Y-related protein SOX13 is a diabetes autoantigen expressed in pancreatic islets". Diabetes 49 (4): 555–61. Apr 2000. doi:10.2337/diabetes.49.4.555. PMID 10871192. 
• "Autoantibodies to ICA12 (SOX-13) are not specific for Type I diabetes". Diabetologia 43 (11): 1381–4. Nov 2000. doi:10.1007/s001250051542. PMID 11126406. 
• "Antibodies to SOX13 (ICA12) are associated with type 1 diabetes". Autoimmunity 33 (2): 95–101. 2001. doi:10.3109/08916930108995994. PMID 11264788. 
• "ICA12(SOX13) autoantibodies are unlikely to be a useful marker for pre-clinical Type I diabetes". Diabetologia 44 (2): 267. Feb 2001. doi:10.1007/s001250051610. PMID 11270687. 
• "Linkage studies of SOX13, the ICA12 autoantigen gene, in families with type 1 diabetes". Molecular Genetics and Metabolism 72 (4): 356–9. Apr 2001. doi:10.1006/mgme.2000.3136. PMID 11286511. 
• "Antibodies to diabetes-associated autoantigens in Indian patients with Type 1 diabetes: prevalence of anti-ICA512/IA2 and anti-SOX13". Diabetes Research and Clinical Practice 52 (3): 205–11. Jun 2001. doi:10.1016/S0168-8227(01)00230-3. PMID 11323090. 
• "Prevalence of ICA-12 and other autoantibodies in north Indian patients with early-onset diabetes". Annals of the New York Academy of Sciences 958 (1): 214–7. Apr 2002. doi:10.1111/j.1749-6632.2002.tb02972.x. PMID 12021109. Bibcode: 2002NYASA.958..214T. 
• "Increased autoantibodies to SOX13 in Swedish patients with type 1 diabetes". Annals of the New York Academy of Sciences 958 (1): 218–23. Apr 2002. doi:10.1111/j.1749-6632.2002.tb02973.x. PMID 12021110. Bibcode: 2002NYASA.958..218T. 
• "Antibodies to new beta cell antigen ICA12 in Latvian diabetes patients". Annals of the New York Academy of Sciences 958 (1): 297–304. Apr 2002. doi:10.1111/j.1749-6632.2002.tb02991.x. PMID 12021128. Bibcode: 2002NYASA.958..297S. 
• "ICA12 autoantibodies are associated with non-DR3/non-DR4 in patients with latent autoimmune diabetes in adults from northern India". Annals of the New York Academy of Sciences 958 (1): 329–32. Apr 2002. doi:10.1111/j.1749-6632.2002.tb02998.x. PMID 12021135. Bibcode: 2002NYASA.958..329G. 
• "Autoantibodies to the transcriptional factor SOX13 in primary biliary cirrhosis compared with other diseases". Journal of Autoimmunity 19 (4): 251–7. Dec 2002. doi:10.1006/jaut.2002.0622. PMID 12473246. 
• "SOX13 autoantibodies are likely to be a supplementary marker for type 1 diabetes in Korea". Annals of the New York Academy of Sciences 1005 (1): 253–8. Nov 2003. doi:10.1196/annals.1288.038. PMID 14679071. Bibcode: 2003NYASA1005..253P. 

External links

• SOX13+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.