Biology:NFYA

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Nuclear transcription factor Y subunit alpha is a protein that in humans is encoded by the NFYA gene.[1][2]

Function

The protein encoded by this gene is one subunit of a trimeric complex NF-Y, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes.[3] Subunit NFYA associates with a tight dimer composed of the NFYB and NFYC subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the NFYA subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.[4]

NF-Y complex serves as a pioneer factor by promoting chromatin accessibility to facilitate other co-localizing cell type-specific transcription factors.[5]

NF-Y has also been implicated as a central player in transcription start site (TSS) selection in animals.[6] It safeguards the integrity of the nucleosome-depleted region and PIC localization at protein-coding gene promoters.

Interactions

NFYA has been shown to interact with Serum response factor[7] and ZHX1.[7][8] NFYA, NFYB and NFYC form the NFY complex and it has been shown that the NFY complex serves as a pioneer factor by promoting chromatin accessibility to facilitate other co-localizing cell type-specific transcription factors.[3]

References

  1. ↑ "One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes". Genomics 11 (3): 630–4. November 1991. doi:10.1016/0888-7543(91)90070-U. PMID 1774067. 
  2. ↑ "Role of the CCAAT-binding protein CBF/NF-Y in transcription". Trends in Biochemical Sciences 23 (5): 174–8. May 1998. doi:10.1016/S0968-0004(98)01201-8. PMID 9612081. 
  3. ↑ 3.0 3.1 "Histone-fold domain protein NF-Y promotes chromatin accessibility for cell type-specific master transcription factors". Molecular Cell 55 (5): 708–22. September 2014. doi:10.1016/j.molcel.2014.07.005. PMID 25132174. 
  4. ↑ "Entrez Gene: NFYA nuclear transcription factor Y, alpha". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4800. 
  5. ↑ "Histone-fold domain protein NF-Y promotes chromatin accessibility for cell type-specific master transcription factors". Molecular Cell 55 (5): 708–22. September 2014. doi:10.1016/j.molcel.2014.07.005. PMID 25132174.  [verification needed]
  6. ↑ "NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region". Nature Communications 10 (1): 3072. 2019-07-11. doi:10.1038/s41467-019-10905-7. PMID 31296853. Bibcode: 2019NatCo..10.3072O. 
  7. ↑ 7.0 7.1 "Identification of proteins that interact with NF-YA". FEBS Letters 460 (1): 41–5. October 1999. doi:10.1016/S0014-5793(99)01311-3. PMID 10571058. 
  8. ↑ "Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y". Biochemical and Biophysical Research Communications 261 (3): 614–21. August 1999. doi:10.1006/bbrc.1999.1087. PMID 10441475. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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