Biology:GABPA

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

GA-binding protein alpha chain is a protein that in humans is encoded by the GABPA gene.

Function

This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome c oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down syndrome phenotype.

Interactions

GABPA has been shown to interact with Host cell factor C1, Sp1 transcription factor and Sp3 transcription factor.

See also

• ETS transcription factor family
• GABPB2

Further reading

• "Mapping of the human transcription factor GABPA (E4TF1-60) gene to chromosome 21". Genomics 28 (1): 119–22. Jul 1995. doi:10.1006/geno.1995.1117. PMID 7590737. 
• "Regional mapping of two subunits of transcription factor E4TF1 to human chromosome". Japanese Journal of Cancer Research 86 (1): 10–2. Jan 1995. doi:10.1111/j.1349-7006.1995.tb02981.x. PMID 7737900. 
• "Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain". Molecular and Cellular Biology 15 (1): 102–11. Jan 1995. doi:10.1128/MCB.15.1.102. PMID 7799916. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Assignment of the E4TF1-60 gene to human chromosome 21q21.2-q21.3". Gene 166 (2): 337–8. Dec 1995. doi:10.1016/0378-1119(95)00575-7. PMID 8543189. 
• "Functional domains of transcription factor hGABP beta1/E4TF1-53 required for nuclear localization and transcription activation". Nucleic Acids Research 24 (24): 4954–61. Dec 1996. doi:10.1093/nar/24.24.4954. PMID 9016666. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA". Science 279 (5353): 1037–41. Feb 1998. doi:10.1126/science.279.5353.1037. PMID 9461436. Bibcode: 1998Sci...279.1037B. 
• "Functional interactions of transcription factor human GA-binding protein subunits". The Journal of Biological Chemistry 273 (45): 29302–8. Nov 1998. doi:10.1074/jbc.273.45.29302. PMID 9792629. 
• "Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain". Genes & Development 13 (1): 76–86. Jan 1999. doi:10.1101/gad.13.1.76. PMID 9887101. 
• "GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes". Proceedings of the National Academy of Sciences of the United States of America 96 (4): 1541–6. Feb 1999. doi:10.1073/pnas.96.4.1541. PMID 9990060. Bibcode: 1999PNAS...96.1541B. 
• "Synergistic transcriptional activation by hGABP and select members of the activation transcription factor/cAMP response element-binding protein family". The Journal of Biological Chemistry 274 (50): 35475–82. Dec 1999. doi:10.1074/jbc.274.50.35475. PMID 10585419. 
• "Human nuclear respiratory factor 2 alpha subunit cDNA: isolation, subcloning, sequencing, and in situ hybridization of transcripts in normal and monocularly deprived macaque visual system". The Journal of Comparative Neurology 417 (2): 221–32. Feb 2000. doi:10.1002/(SICI)1096-9861(20000207)417:2<221::AID-CNE7>3.0.CO;2-4. PMID 10660899. 
• "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP". The EMBO Journal 19 (4): 683–90. Feb 2000. doi:10.1093/emboj/19.4.683. PMID 10675337. 
• "The DNA sequence of human chromosome 21". Nature 405 (6784): 311–9. May 2000. doi:10.1038/35012518. PMID 10830953. Bibcode: 2000Natur.405..311H. 
• "Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter". Journal of Molecular Biology 306 (5): 985–96. Mar 2001. doi:10.1006/jmbi.2000.4335. PMID 11237613. https://iris.unito.it/bitstream/2318/141203/1/Sp1%20and%20Sp3%20Physically%20Interact%20and%20Co_4aperto.pdf. 
• "Nitric oxide-induced transcriptional up-regulation of protective genes by Nrf2 via the antioxidant response element counteracts apoptosis of neuroblastoma cells". The Journal of Biological Chemistry 279 (19): 20096–107. May 2004. doi:10.1074/jbc.M312492200. PMID 14985350. 
• "Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein". The Journal of Biological Chemistry 279 (22): 23052–60. May 2004. doi:10.1074/jbc.M401368200. PMID 15020583. 

External links

• FactorBook GABP