Biology:HOXB5

Short description: Protein-coding gene in humans

Generic protein structure example

Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.

Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.

See also

• Homeobox

Further reading

• "Cooperative DNA binding of the highly conserved human Hox 2.1 homeodomain gene product". The New Biologist 4 (5): 558–68. May 1992. PMID 1355360. 
• "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation; Research in Biological Diversity 45 (1): 61–9. Oct 1990. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366. 
• "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation; Research in Biological Diversity 40 (3): 191–7. Jun 1989. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724. 
• "The human HOX gene family". Nucleic Acids Research 17 (24): 10385–402. Dec 1989. doi:10.1093/nar/17.24.10385. PMID 2574852. 
• "Organization of human class I homeobox genes". Genome 31 (2): 745–56. 1990. doi:10.1139/g89-133. PMID 2576652. 
• "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proceedings of the National Academy of Sciences of the United States of America 83 (23): 9104–8. Dec 1986. doi:10.1073/pnas.83.23.9104. PMID 2878432. Bibcode: 1986PNAS...83.9104R. 
• "Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus". Cell 43 (1): 9–18. Nov 1985. doi:10.1016/0092-8674(85)90007-8. PMID 3000607. 
• "Construction of a genetic map of human chromosome 17 by use of chromosome-mediated gene transfer". Proceedings of the National Academy of Sciences of the United States of America 85 (22): 8563–7. Nov 1988. doi:10.1073/pnas.85.22.8563. PMID 3186746. Bibcode: 1988PNAS...85.8563X. 
• "A human homoeo box gene specifically expressed in spinal cord during embryonic development". Nature 320 (6064): 763–5. 1986. doi:10.1038/320763a0. PMID 3453105. Bibcode: 1986Natur.320..763S. 
• "Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos". Cell 43 (1): 19–28. Nov 1985. doi:10.1016/0092-8674(85)90008-X. PMID 4075393. 
• "Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila". Cell 38 (3): 667–73. Oct 1984. doi:10.1016/0092-8674(84)90261-7. PMID 6091895. 
• "Cooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitro". Molecular and Cellular Biology 13 (8): 4609–17. Aug 1993. doi:10.1128/mcb.13.8.4609. PMID 8101633. 
• "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics 73 (1–2): 114–5. 1996. doi:10.1159/000134320. PMID 8646877. 
• "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies". Journal of Assisted Reproduction and Genetics 13 (2): 177–81. Feb 1996. doi:10.1007/BF02072541. PMID 8688592. 
• "Localization of the HoxB5 protein in the developing CNS of late gestational mouse embryos". International Journal of Developmental Neuroscience 14 (5): 567–73. Aug 1996. doi:10.1016/0736-5748(96)00052-4. PMID 8930688. 
• "Thyroid hormone affects embryonic mouse lung branching morphogenesis and cellular differentiation". American Journal of Physiology. Lung Cellular and Molecular Physiology 282 (3): L359-69. Mar 2002. doi:10.1152/ajplung.00400.2000. PMID 11839528. 
• "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. Feb 2002. doi:10.1002/tera.10009. PMID 11857506. 

External links

• HOXB5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: P02833 (Drosophila melanogaster Homeotic protein antennapedia) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.