Biology:ZNF638

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Zinc finger protein 638 is a protein that in humans is encoded by the ZNF638 gene.[1][2]

The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.[2]

Interactions

ZNF638 has been shown to interact with FHL2.[3]

References

  1. "A large DNA-binding nuclear protein with RNA recognition motif and serine/arginine-rich domain". J Biol Chem 271 (21): 12525–31. Jul 1996. doi:10.1074/jbc.271.21.12525. PMID 8647861. 
  2. 2.0 2.1 "Entrez Gene: ZNF638 zinc finger protein 638". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27332. 
  3. Ng, Enders Kai On; Chan Kwok Keung; Wong Chi Hang; Tsui Stephen Kwok Wing; Ngai Sai Ming; Lee Simon Ming Yuen; Kotaka Masayo; Lee Cheuk Yu et al. (2002). "Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220". J. Cell. Biochem. (United States) 84 (3): 556–66. doi:10.1002/jcb.10041. ISSN 0730-2312. PMID 11813260. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.