Biology:ILF2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ILF2 gene.[1][2]
Function
Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.[2]
Interactions
ILF2 has been shown to interact with CDC5L[3] and DNA-PKcs.[4]
ILF2 and ILF3 have been identified as autoantigens in mice with induced lupus,[5][6] in canine systemic rheumatic autoimmune disease,[7][8] and as a rare finding in humans with autoimmune disease.[9]
References
- ↑ "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90". The Journal of Biological Chemistry 269 (32): 20691–9. August 1994. doi:10.1016/S0021-9258(17)32048-3. PMID 7519613.
- ↑ 2.0 2.1 "Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3608.
- ↑ "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal 19 (23): 6569–81. December 2000. doi:10.1093/emboj/19.23.6569. PMID 11101529.
- ↑ "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry 273 (4): 2136–45. January 1998. doi:10.1074/jbc.273.4.2136. PMID 9442054.
- ↑ "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity". The Journal of Biological Chemistry 274 (49): 34598–604. December 1999. doi:10.1074/jbc.274.49.34598. PMID 10574923. https://cdr.lib.unc.edu/downloads/dr26z6575.
- ↑ "Induction of lupus-related specific autoantibodies by non-specific inflammation caused by an intraperitoneal injection of n-hexadecane in BALB/c mice". Toxicology 218 (2–3): 186–96. February 2006. doi:10.1016/j.tox.2005.10.011. PMID 16309812.
- ↑ "ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease". Scientific Reports 8 (1): 4852. March 2018. doi:10.1038/s41598-018-23034-w. PMID 29556082. Bibcode: 2018NatSR...8.4852B.
- ↑ Hanna, Bremer (2018) (in en). Canine immune-mediated disease. Acta Universitatis agriculturae Sueciae. ISBN 978-91-7760-166-1. https://pub.epsilon.slu.se/15432/.
- ↑ "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity". The Journal of Biological Chemistry 274 (49): 34598–604. December 1999. doi:10.1074/jbc.274.49.34598. PMID 10574923. https://cdr.lib.unc.edu/downloads/dr26z6575.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Mapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates". Journal of Interferon & Cytokine Research 16 (12): 1035–8. December 1996. doi:10.1089/jir.1996.16.1035. PMID 8974006.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry 273 (4): 2136–45. January 1998. doi:10.1074/jbc.273.4.2136. PMID 9442054.
- "Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR". Biochemistry 38 (19): 6361–8. May 1999. doi:10.1021/bi982410u. PMID 10320367.
- "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity". The Journal of Biological Chemistry 274 (49): 34598–604. December 1999. doi:10.1074/jbc.274.49.34598. PMID 10574923. https://cdr.lib.unc.edu/downloads/dr26z6575.
- "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal 19 (23): 6569–81. December 2000. doi:10.1093/emboj/19.23.6569. PMID 11101529.
- "Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase". The Journal of Biological Chemistry 276 (35): 32522–30. August 2001. doi:10.1074/jbc.M104408200. PMID 11438540.
- "The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells". Molecular and Cellular Biology 22 (1): 343–56. January 2002. doi:10.1128/MCB.22.1.343-356.2002. PMID 11739746.
- "Directed proteomic analysis of the human nucleolus". Current Biology 12 (1): 1–11. January 2002. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
- "Host cell proteins binding to the encapsidation signal epsilon in hepatitis B virus RNA". Archives of Virology 147 (3): 471–91. March 2002. doi:10.1007/s007050200001. PMID 11958450.
- "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell 13 (11): 4100–9. November 2002. doi:10.1091/mbc.E02-05-0271. PMID 12429849.
- "Regulation of alternative splicing by SRrp86 and its interacting proteins". Molecular and Cellular Biology 23 (21): 7437–47. November 2003. doi:10.1128/MCB.23.21.7437-7447.2003. PMID 14559993.
- "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. January 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
- "NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function". Experimental Cell Research 305 (2): 312–23. May 2005. doi:10.1016/j.yexcr.2004.12.030. PMID 15817156.
- "ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing". Molecular and Cellular Biology 25 (16): 6956–63. August 2005. doi:10.1128/MCB.25.16.6956-6963.2005. PMID 16055709.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
External links
- ILF2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Interleukin enhancer-binding factor 2 (ILF2)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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