Biology:IFI16
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.[1][2][3]
Function
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53,[4] retinoblastoma-1 and BRCA1.[5] It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway.[3] IFI16 has been shown to play a role in the sensing of intracellular DNA[6] - a hallmark of virally infected cells - and has also been linked to the death of HIV-infected helper CD4 T cells by pyroptosis, a highly inflammatory form of programmed cell death.[7][8] Recently, it has been shown how IFI16, once extracellularly released, can induce inflammation upon TLR4 binding, acting as a DAMP.[9]
References
- ↑ "A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells". Immunogenetics 36 (6): 369–76. Oct 1992. doi:10.1007/bf00218044. PMID 1526658.
- ↑ "Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization". Immunogenetics 40 (6): 415–24. Dec 1994. doi:10.1007/bf00177824. PMID 7959953.
- ↑ 3.0 3.1 "Entrez Gene: IFI16 interferon, gamma-inducible protein 16". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3428.
- ↑ Ouchi, Mutsuko; Ouchi, Toru (2008-01-01). "Role of IFI16 in DNA damage and checkpoint". Frontiers in Bioscience 13 (13): 236–239. doi:10.2741/2673. ISSN 1093-9946. PMID 17981541.
- ↑ Dutta, Dipanjan; Dutta, Sujoy; Veettil, Mohanan Valiya; Roy, Arunava; Ansari, Mairaj Ahmed; Iqbal, Jawed; Chikoti, Leela; Kumar, Binod et al. (2015-06-01). "BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses". PLOS Pathogens 11 (6): e1005030. doi:10.1371/journal.ppat.1005030. ISSN 1553-7374. PMID 26121674.
- ↑ "IFI16 is an innate immune sensor for intracellular DNA". Nat. Immunol. 11 (11): 997–1004. 2010. doi:10.1038/ni.1932. PMID 20890285.
- ↑ "IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV". Science 343 (6169): 428–32. 2014. doi:10.1126/science.1243640. PMID 24356113. Bibcode: 2014Sci...343..428M.
- ↑ "Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection". Nature 505 (7484): 509–14. 2014. doi:10.1038/nature12940. PMID 24356306. Bibcode: 2014Natur.505..509D.
- ↑ Iannucci A, Caneparo V, Raviola S, Debernardi I, Colangelo D, et al. (2020) Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding. PLOS Pathogens 16(9): e1008811. https://doi.org/10.1371/journal.ppat.1008811
Further reading
- "IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines.". J. Cell. Biochem. 57 (1): 39–51. 1995. doi:10.1002/jcb.240570106. PMID 7536752.
- "The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression.". Immunogenetics 41 (1): 40–3. 1995. doi:10.1007/BF00188431. PMID 7806273.
- "The human interferon-inducible protein, IFI 16, is a repressor of transcription.". J. Biol. Chem. 273 (27): 17172–7. 1998. doi:10.1074/jbc.273.27.17172. PMID 9642285.
- "Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing.". Biochemistry 37 (34): 11924–31. 1998. doi:10.1021/bi981069a. PMID 9718316.
- "The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations.". J. Leukoc. Biol. 64 (4): 546–54. 1998. doi:10.1002/jlb.64.4.546. PMID 9766636.
- "Novel properties of the protein kinase CK2-site-regulated nuclear- localization sequence of the interferon-induced nuclear factor IFI 16.". Biochem. J. 353 (Pt 1): 69–77. 2001. doi:10.1042/0264-6021:3530069. PMID 11115400.
- "Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16.". Oncogene 19 (52): 6033–42. 2001. doi:10.1038/sj.onc.1204005. PMID 11146555.
- "Immunohistochemical expression analysis of the human interferon-inducible gene IFI16, a member of the HIN200 family, not restricted to hematopoietic cells.". J. Interferon Cytokine Res. 22 (7): 815–21. 2003. doi:10.1089/107999002320271413. PMID 12184920. https://iris.unito.it/bitstream/2318/39497/1/GariglioJIFNCytRes02.pdf.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.". Nat. Med. 9 (2): 191–7. 2003. doi:10.1038/nm822. PMID 12539042.
- "Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16.". J. Cell. Biochem. 89 (1): 80–93. 2003. doi:10.1002/jcb.10475. PMID 12682910.
- "Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence.". Oncogene 22 (31): 4831–40. 2003. doi:10.1038/sj.onc.1206754. PMID 12894224.
- "IFI16 as a negative regulator in the regulation of p53 and p21(Waf1).". J. Biol. Chem. 278 (42): 40899–904. 2003. doi:10.1074/jbc.M308012200. PMID 12925527.
- "A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway.". Oncogene 22 (55): 8931–8. 2004. doi:10.1038/sj.onc.1207057. PMID 14654789.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The interferon-inducible IFI16 gene inhibits tube morphogenesis and proliferation of primary, but not HPV16 E6/E7-immortalized human endothelial cells.". Exp. Cell Res. 293 (2): 331–45. 2004. doi:10.1016/j.yexcr.2003.10.014. PMID 14729471.
- "Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation.". J. Biol. Chem. 279 (19): 20339–44. 2004. doi:10.1074/jbc.M400344200. PMID 14990579.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
External links
- IFI16+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
PDB gallery | |
|---|---|
|
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
