Biology:NEUROD2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.

Function

This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.

Interactions

NEUROD2 has been shown to interact with Protein kinase N1.

Further reading

• "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family". Molecular and Cellular Biology 16 (10): 5792–800. Oct 1996. doi:10.1128/mcb.16.10.5792. PMID 8816493. 
• "Phosphorylation and spatiotemporal distribution of KW8 (NDRF/NeuroD2), a NeuroD family basic helix-loop-helix protein". Brain Research. Molecular Brain Research 60 (1): 107–14. Sep 1998. doi:10.1016/S0169-328X(98)00176-4. PMID 9748526. 
• "Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF)1". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1445 (1): 142–7. Apr 1999. doi:10.1016/s0167-4781(99)00038-x. PMID 10209266. 
• "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Research. Molecular Brain Research 74 (1–2): 126–34. Dec 1999. doi:10.1016/S0169-328X(99)00273-9. PMID 10640683. 
• "Physical map of 17p13 and the genes adjacent to p53". Genomics 63 (1): 60–8. Jan 2000. doi:10.1006/geno.1999.6062. PMID 10662545. 
• "NeuroD homologue expression during cortical development in the human brain". Journal of Child Neurology 16 (11): 849–53. Nov 2001. doi:10.1177/08830738010160111201. PMID 11732772. 
• "The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion". Mechanisms of Development 113 (1): 85–90. Apr 2002. doi:10.1016/S0925-4773(01)00665-7. PMID 11900979. 
• "NEUROD1 acts in vitro as an upstream regulator of NEUROD2 in trophoblast cells". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1676 (1): 96–103. Jan 2004. doi:10.1016/j.bbaexp.2003.10.002. PMID 14732494. 
• "A possible impact of the neuroD2 transcription factor on the development of drug abusing behavior". Molecular Psychiatry 11 (6): 525–7. Jun 2006. doi:10.1038/sj.mp.4001825. PMID 16607387. 

External links

• NEUROD2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.