Biology:FOXK2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Forkhead box protein K2 is a protein that in humans is encoded by the FOXK2 gene.

The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements.

Further reading

• "Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein ILF.". Genomics 13 (3): 665–71. 1992. doi:10.1016/0888-7543(92)90139-J. PMID 1339390. 
• "Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat.". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7739–43. 1991. doi:10.1073/pnas.88.17.7739. PMID 1909027. Bibcode: 1991PNAS...88.7739L. 
• "Constitutive binding of the transcription factor interleukin-2 (IL-2) enhancer binding factor to the IL-2 promoter.". J. Biol. Chem. 272 (12): 7736–45. 1997. doi:10.1074/jbc.272.12.7736. PMID 9065434. 
• "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166. 
• "Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a).". Proteins 49 (4): 543–53. 2003. doi:10.1002/prot.10227. PMID 12402362. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins.". J. Biol. Chem. 281 (25): 17400–9. 2006. doi:10.1074/jbc.M600478200. PMID 16624804. 
• "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.". Nature 440 (7087): 1045–9. 2006. doi:10.1038/nature04689. PMID 16625196. Bibcode: 2006Natur.440.1045Z. 
• "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. 2006. doi:10.1038/nbt1240. PMID 16964243. 

External links

• FOXK2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: Q01167 (Forkhead box protein K2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.