Biology:HOXD3
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Homeobox protein Hox-D3 is a protein that in humans is encoded by the HOXD3 gene.[1][2][3]
Function
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes.[3]
See also
References
- ↑ "Nomenclature for human homeobox genes". Genomics 7 (3): 460. Jul 1990. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
- ↑ "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. Nov 1992. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
- ↑ 3.0 3.1 "Entrez Gene: HOXD3 homeobox D3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3232.
Further reading
- "Cloning and sequencing of the human homeobox gene HOX4A". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1132 (3): 332–4. Oct 1992. doi:10.1016/0167-4781(92)90173-w. PMID 1358204.
- "Coordinate regulation of HOX genes in human hematopoietic cells". Proceedings of the National Academy of Sciences of the United States of America 88 (14): 6348–52. Jul 1991. doi:10.1073/pnas.88.14.6348. PMID 1712489. Bibcode: 1991PNAS...88.6348M.
- "The human HOX gene family". Nucleic Acids Research 17 (24): 10385–402. Dec 1989. doi:10.1093/nar/17.24.10385. PMID 2574852.
- "Organization of human class I homeobox genes". Genome 31 (2): 745–56. 1990. doi:10.1139/g89-133. PMID 2576652.
- "Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13". American Journal of Human Genetics 41 (1): 1–15. Jul 1987. PMID 2886047.
- "Overexpression of the HOX4A (HOXD3) homeobox gene in human erythroleukemia HEL cells results in altered adhesive properties". Blood 85 (10): 2786–94. May 1995. doi:10.1182/blood.V85.10.2786.bloodjournal85102786. PMID 7742539.
- "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". The EMBO Journal 13 (14): 3339–47. Jul 1994. doi:10.1002/j.1460-2075.1994.tb06636.x. PMID 7913891.
- "Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands". Developmental Biology 195 (1): 1–15. Mar 1998. doi:10.1006/dbio.1997.8827. PMID 9520319.
- "Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster". American Journal of Human Genetics 65 (1): 104–10. Jul 1999. doi:10.1086/302467. PMID 10364522.
- "Homeobox B3 promotes capillary morphogenesis and angiogenesis". The Journal of Cell Biology 148 (2): 343–51. Jan 2000. doi:10.1083/jcb.148.2.343. PMID 10648567.
- "Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1". Cytogenetics and Cell Genetics 90 (1–2): 151–3. 2000. doi:10.1159/000015651. PMID 11060466.
- "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. Feb 2002. doi:10.1002/tera.10009. PMID 11857506.
- "Transduction of HOXD3-antisense into human melanoma cells results in decreased invasive and motile activities". Clinical & Experimental Metastasis 19 (6): 503–11. 2002. doi:10.1023/A:1020346211686. PMID 12405287.
- "The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis". The Journal of Biological Chemistry 279 (6): 4862–8. Feb 2004. doi:10.1074/jbc.M305190200. PMID 14610084.
- "HoxD3 accelerates wound healing in diabetic mice". The American Journal of Pathology 163 (6): 2421–31. Dec 2003. doi:10.1016/S0002-9440(10)63597-3. PMID 14633614.
- "Retroviral delivery of homeobox D3 gene induces cerebral angiogenesis in mice". Journal of Cerebral Blood Flow and Metabolism 24 (11): 1280–7. Nov 2004. doi:10.1097/01.WCB.0000141770.09022.AB. PMID 15545924.
External links
- HOXD3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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