Biology:RFX2
 Generic protein structure example |
DNA-binding protein RFX2 is a protein that in humans is encoded by the RFX2 gene.[1][2]
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.[2]
References
- ↑ "The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19". Genomics 13 (4): 1307–10. Sep 1992. doi:10.1016/0888-7543(92)90052-T. PMID 1505960.
- ↑ 2.0 2.1 "Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5990.
Further reading
- "RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.". Mol. Cell. Biol. 14 (2): 1230–44. 1994. doi:10.1128/MCB.14.2.1230. PMID 8289803.
- "Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins.". Genomics 35 (1): 227–30. 1996. doi:10.1006/geno.1996.0343. PMID 8661125. https://zenodo.org/record/1229693.
- "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. 1997. doi:10.1101/gr.6.9.807. PMID 8889549.
- "Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.". Mol. Cell. Biol. 19 (6): 3940–50. 1999. doi:10.1128/MCB.19.6.3940. PMID 10330134.
- "Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.". J. Biol. Chem. 277 (1): 836–42. 2002. doi:10.1074/jbc.M108638200. PMID 11682486.
- "The RFX family interacts at the collagen (COL1A2) start site and represses transcription.". J. Biol. Chem. 277 (28): 24926–37. 2002. doi:10.1074/jbc.M111712200. PMID 11986307.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.". Arch. Dermatol. Res. 295 (11): 482–9. 2004. doi:10.1007/s00403-004-0456-5. PMID 15024578.
- "RFX2 is a potential transcriptional regulatory factor for histone H1t and other genes expressed during the meiotic phase of spermatogenesis.". Biol. Reprod. 71 (5): 1551–9. 2005. doi:10.1095/biolreprod.104.032268. PMID 15229132.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
External links
- RFX2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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