Biology:ZEB1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.[1][2][3]
ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.[3][2] ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain.[4] The structure of the homeodomain is shown on the right.
Clinical significance
Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. ZEB1 downregulates E-cadherin and induces epithelial to mesenchymal transition in breast and other carcinomas[5] A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.[6] Overexpression of ZEB1 has been identified as a potential risk factor for recurrence and poor prognosis in several types of cancers.[7]
References
- ↑ "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics 14 (1): 194–6. September 1992. doi:10.1016/S0888-7543(05)80307-6. PMID 1427828.
- ↑ 2.0 2.1 "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science 254 (5039): 1791–4. December 1991. doi:10.1126/science.1840704. PMID 1840704. Bibcode: 1991Sci...254.1791W.
- ↑ 3.0 3.1 "Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6935.
- ↑ "Homeodomain proteins: an update". Chromosoma 125 (3): 497–521. July 2016. doi:10.1007/s00412-015-0543-8. PMID 26464018.
- ↑ "DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells". Oncogene 24 (14): 2375–85. March 2005. doi:10.1038/sj.onc.1208429. PMID 15674322.
- ↑ "Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1". Laboratory Investigation; A Journal of Technical Methods and Pathology 94 (4): 362–70. April 2014. doi:10.1038/labinvest.2013.153. PMID 24468793.
- ↑ "ZEB1: Catalyst of immune escape during tumor metastasis". Biomed Pharmacother 153: 113490. September 2022. doi:10.1016/j.biopha.2022.113490. PMID 36076506.
Further reading
- "BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription". Molecular and Cellular Biology 14 (10): 6773–88. October 1994. doi:10.1128/MCB.14.10.6773. PMID 7935395.
- "Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene". Journal of Biochemistry 114 (6): 849–55. December 1993. doi:10.1093/oxfordjournals.jbchem.a124267. PMID 8138542.
- "Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6". Molecular and Cellular Biology 18 (1): 10–8. January 1998. doi:10.1128/mcb.18.1.10. PMID 9418848.
- "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators". The EMBO Journal 17 (17): 5129–40. September 1998. doi:10.1093/emboj/17.17.5129. PMID 9724649.
- "ZEB represses transcription through interaction with the corepressor CtBP". Proceedings of the National Academy of Sciences of the United States of America 96 (12): 6683–8. June 1999. doi:10.1073/pnas.96.12.6683. PMID 10359772. Bibcode: 1999PNAS...96.6683P.
- "Tip60 is a cell-type-specific transcriptional regulator". Journal of Biochemistry 129 (4): 635–41. April 2001. doi:10.1093/oxfordjournals.jbchem.a002901. PMID 11275565.
- "Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology". Journal of Bone and Mineral Research 16 (12): 2192–204. December 2001. doi:10.1359/jbmr.2001.16.12.2192. PMID 11760832.
- "Effects of HIV-1 Nef on cellular gene expression profiles". Journal of Biomedical Science 9 (1): 82–96. 2002. doi:10.1007/BF02256581. PMID 11810028.
- "Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression". The Journal of Biological Chemistry 277 (42): 39209–16. October 2002. doi:10.1074/jbc.M206400200. PMID 12161443.
- "Cell-specific phosphorylation of Zfhep transcription factor". Biochemical and Biophysical Research Communications 296 (2): 368–73. August 2002. doi:10.1016/S0006-291X(02)00880-X. PMID 12163027.
- "Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway". The EMBO Journal 22 (10): 2443–52. May 2003. doi:10.1093/emboj/cdg225. PMID 12743038.
- "Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins". The EMBO Journal 22 (10): 2453–62. May 2003. doi:10.1093/emboj/cdg226. PMID 12743039.
- "Transcriptional activation by the zinc-finger homeodomain protein delta EF1 in estrogen signaling cascades". DNA and Cell Biology 23 (1): 25–34. January 2004. doi:10.1089/104454904322745907. PMID 14965470.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. August 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10". American Journal of Medical Genetics. Part A 130A (4): 372–7. November 2004. doi:10.1002/ajmg.a.30267. PMID 15384081.
External links
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