Biology:Testicular receptor 4

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Testicular receptor 4 also known as NR2C2 (nuclear receptor subfamily 2, group C, member 2) is a protein that in humans is encoded by the NR2C2 gene.

The testicular receptor 4 is a member of the nuclear receptor family of transcription factors.

Interactions

Testicular receptor 4 has been shown to interact with

• Androgen receptor,
• Estrogen receptor alpha, and
• Hepatocyte nuclear factor 4 alpha.

See also

• Testicular receptor

Further reading

• "TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily". Molecular Endocrinology 8 (12): 1667–80. Dec 1994. doi:10.1210/mend.8.12.7708055. PMID 7708055. https://zenodo.org/record/1236241. 
• "Induction of the intronic enhancer of the human ciliary neurotrophic factor receptor (CNTFRalpha) gene by the TR4 orphan receptor. A member of steroid receptor superfamily". The Journal of Biological Chemistry 272 (5): 3109–16. Jan 1997. doi:10.1074/jbc.272.5.3109. PMID 9006963. 
• "A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4". The Journal of Biological Chemistry 273 (39): 25209–15. Sep 1998. doi:10.1074/jbc.273.39.25209. PMID 9737983. 
• "Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily". Proceedings of the National Academy of Sciences of the United States of America 96 (26): 14724–9. Dec 1999. doi:10.1073/pnas.96.26.14724. PMID 10611280. Bibcode: 1999PNAS...9614724L. 
• "Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells". The Journal of Biological Chemistry 276 (44): 40417–23. Nov 2001. doi:10.1074/jbc.M104765200. PMID 11509567. 
• "Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation". Molecular and Cellular Biology 21 (21): 7207–17. Nov 2001. doi:10.1128/MCB.21.21.7207-7217.2001. PMID 11585904. 
• "Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells". The Journal of Biological Chemistry 277 (17): 14622–8. Apr 2002. doi:10.1074/jbc.M110051200. PMID 11844790. 
• "An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer". The EMBO Journal 21 (13): 3434–42. Jul 2002. doi:10.1093/emboj/cdf340. PMID 12093744. 
• "Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation". The Journal of Biological Chemistry 278 (9): 7709–17. Feb 2003. doi:10.1074/jbc.M207116200. PMID 12486131. 
• "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4". The Journal of Biological Chemistry 278 (11): 9353–60. Mar 2003. doi:10.1074/jbc.M205944200. PMID 12522137. 
• "TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway". Journal of Molecular Biology 326 (1): 105–15. Feb 2003. doi:10.1016/S0022-2836(02)01404-3. PMID 12547194. 
• "Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes". Journal of Dermatological Science 31 (1): 65–71. Feb 2003. doi:10.1016/S0923-1811(02)00152-4. PMID 12615366. 
• "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". The EMBO Journal 22 (23): 6277–88. Dec 2003. doi:10.1093/emboj/cdg605. PMID 14633987. 
• "TAB3, a new binding partner of the protein kinase TAK1". The Biochemical Journal 378 (Pt 1): 27–34. Feb 2004. doi:10.1042/BJ20031794. PMID 14670075. 
• "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology 6 (2): 97–105. Feb 2004. doi:10.1038/ncb1086. PMID 14743216. 

External links

• FactorBook TR4