Biology:SPIB
From HandWiki
Short description: Protein that controls transcription of a set of genes in eukaryotes
 Generic protein structure example |
Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.[1][2]
Function
SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1; MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).[supplied by OMIM][2]
Interactions
SPIB has been shown to interact with MAPK3[3] and MAPK8.[3]
References
- ↑ "Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1". Molecular and Cellular Biology 12 (10): 4297–304. October 1992. doi:10.1128/mcb.12.10.4297. PMID 1406622.
- ↑ 2.0 2.1 "Entrez Gene: SPIB Spi-B transcription factor (Spi-1/PU.1 related)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6689.
- ↑ 3.0 3.1 "Differential phosphorylations of Spi-B and Spi-1 transcription factors". Oncogene 12 (4): 863–73. February 1996. PMID 8632909.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Differential phosphorylations of Spi-B and Spi-1 transcription factors". Oncogene 12 (4): 863–73. February 1996. PMID 8632909.
- "An alternatively spliced isoform of the Spi-B transcription factor". Biochemical and Biophysical Research Communications 223 (2): 257–63. June 1996. doi:10.1006/bbrc.1996.0881. PMID 8670269.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1". The Journal of Biological Chemistry 274 (16): 11115–24. April 1999. doi:10.1074/jbc.274.16.11115. PMID 10196196.
- "Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells". British Journal of Haematology 116 (2): 429–35. February 2002. doi:10.1046/j.1365-2141.2002.03271.x. PMID 11841448.
- "Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb". Cell Growth & Differentiation 13 (2): 69–75. February 2002. PMID 11864910.
- "The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development". Blood 101 (3): 1015–23. February 2003. doi:10.1182/blood-2002-02-0438. PMID 12393575.
- "The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development". The Journal of Experimental Medicine 200 (11): 1503–9. December 2004. doi:10.1084/jem.20041231. PMID 15583020. PMC 2211952. https://pure.uva.nl/ws/files/4029340/45204_205399y.pdf.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter". The Journal of Biological Chemistry 280 (52): 43264–71. December 2005. doi:10.1074/jbc.M508245200. PMID 16263717.
- "Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B". Blood 107 (6): 2446–52. March 2006. doi:10.1182/blood-2005-05-2090. PMID 16317090.
External links
- SPIB+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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