Biology:HSF4
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Heat shock factor protein 4 is a protein that in humans is encoded by the HSF4 gene.[1][2][3][4]
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.[4]
See also
References
- ↑ "HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator". Mol Cell Biol 17 (1): 469–81. Jan 1997. doi:10.1128/mcb.17.1.469. PMID 8972228.
- ↑ "The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing". J Biol Chem 274 (39): 27845–56. Nov 1999. doi:10.1074/jbc.274.39.27845. PMID 10488131.
- ↑ "Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract". Nat Genet 31 (3): 276–8. Jun 2002. doi:10.1038/ng921. PMID 12089525.
- ↑ 4.0 4.1 "Entrez Gene: HSF4 heat shock transcription factor 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3299.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D.
- "A homozygous splice mutation in the HSF4 gene is associated with an autosomal recessive congenital cataract.". Invest. Ophthalmol. Vis. Sci. 45 (8): 2716–21. 2004. doi:10.1167/iovs.03-1370. PMID 15277496.
- "Developmentally dictated expression of heat shock factors: exclusive expression of HSF4 in the postnatal lens and its specific interaction with alphaB-crystallin heat shock promoter.". J. Biol. Chem. 279 (43): 44497–503. 2004. doi:10.1074/jbc.M405813200. PMID 15308659.
- "Locus heterogeneity in autosomal recessive congenital cataracts: linkage to 9q and germline HSF4 mutations.". Hum. Genet. 117 (5): 452–9. 2005. doi:10.1007/s00439-005-1309-9. PMID 15959809.
- "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. 2006. doi:10.1007/s00335-005-0075-2. PMID 16341674.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Heat shock transcription factor (Hsf)-4b recruits Brg1 during the G1 phase of the cell cycle and regulates the expression of heat shock proteins.". J. Cell. Biochem. 98 (6): 1528–42. 2006. doi:10.1002/jcb.20865. PMID 16552721.
- "Novel HSF4 mutation causes congenital total white cataract in a Chinese family.". Am. J. Ophthalmol. 142 (2): 298–303. 2006. doi:10.1016/j.ajo.2006.03.056. PMID 16876512.
External links
- HSF4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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