Biology:MXD3
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
MAX dimerization protein 3 is a protein that in humans is encoded by the MXD3 gene located on Chromosome 5.[1][2]
MXD3 is a basic helix-loop-helix protein belonging to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex.[2] MXD3 is a transcriptional repressor that is specifically expressed during S phase of the cell cycle.[3] The protein is implicated in both normal neural development and in the development of brain cancer. In medulloblastoma cells, MXD3 binds E-box sequences, leading to increased cell proliferation at moderate MXD3 levels but increased cell death and apoptosis at higher expression levels.[4]
References
- ↑ "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.". EMBO J 14 (22): 5646–59. November 1995. doi:10.1002/j.1460-2075.1995.tb00252.x. PMID 8521822.
- ↑ 2.0 2.1 "Entrez Gene: MXD3 MAX dimerization protein 3". https://www.ncbi.nlm.nih.gov/gene/83463.
- ↑ "The transcriptional repressor gene Mad3 is a novel target for regulation by E2F1.". Biochem J 370 (1): 307–13. February 2003. doi:10.1042/bj20021583. PMID 12444919.
- ↑ "Role of MXD3 in proliferation of DAOY human medulloblastoma cells.". PLOS ONE 7 (7): e38508. July 2012. doi:10.1371/journal.pone.0038508. PMID 22808009. Bibcode: 2012PLoSO...738508B.
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