Biology:SOX12
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SOX12 is a protein that in humans is encoded by the SOX12 gene.[1][2] Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11.[3] Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.[4]
Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.[2]
References
- ↑ "SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue". Hum Mol Genet 6 (7): 1069–77. Aug 1997. doi:10.1093/hmg/6.7.1069. PMID 9215677.
- ↑ 2.0 2.1 "Entrez Gene: SOX12 SRY (sex determining region Y)-box 12". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6666.
- ↑ "Sox12 Deletion in the Mouse Reveals Nonreciprocal Redundancy with the Related Sox4 and Sox11 Transcription Factors". Mol. Cell. Biol. 28 (15): 4675–87. August 2008. doi:10.1128/MCB.00338-08. PMID 18505825.
- ↑ "The three SoxC proteins—Sox4, Sox11 and Sox12—exhibit overlapping expression patterns and molecular properties". Nucleic Acids Res. 36 (9): 3101–17. May 2008. doi:10.1093/nar/gkn162. PMID 18403418.
Further reading
- "Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators". Dev. Biol. 227 (2): 239–55. 2001. doi:10.1006/dbio.2000.9883. PMID 11071752.
- Weiss MA (2001). "Floppy SOX: mutual induced fit in hmg (high-mobility group) box-DNA recognition". Mol. Endocrinol. 15 (3): 353–62. doi:10.1210/mend.15.3.0617. PMID 11222737.
- "Partial cloning of SOX-11 and SOX-12, two new human SOX genes". Nucleic Acids Res. 21 (12): 2943. 1993. doi:10.1093/nar/21.12.2943. PMID 8332506.
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