Biology:HIVEP2
 Generic protein structure example |
Transcription factor HIVEP2 is a protein that in humans is encoded by the HIVEP2 gene.[1][2][3]
Function
Members of the ZAS family, such as ZAS2 (HIVEP2), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM][3]
References
- ↑ "Mapping of the human gene for the human immunodeficiency virus type 1 enhancer binding protein HIV-EP2 to chromosome 6q23-q24". Genomics 12 (1): 167–70. January 1992. doi:10.1016/0888-7543(92)90423-P. PMID 1733857.
- ↑ "HIV-EP2, a new member of the gene family encoding the human immunodeficiency virus type 1 enhancer-binding protein. Comparison with HIV-EP1/PRDII-BF1/MBP-1". The Journal of Biological Chemistry 266 (13): 8590–4. May 1991. doi:10.1016/S0021-9258(18)93015-2. PMID 2022670.
- ↑ 3.0 3.1 "Entrez Gene: HIVEP2 human immunodeficiency virus type I enhancer binding protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3097.
Further reading
- "Structure and expression of major histocompatibility complex-binding protein 2, a 275-kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class I genes". Proceedings of the National Academy of Sciences of the United States of America 89 (19): 8971–5. October 1992. doi:10.1073/pnas.89.19.8971. PMID 1409593. Bibcode: 1992PNAS...89.8971V.
- "Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties". Proceedings of the National Academy of Sciences of the United States of America 87 (22): 8707–10. November 1990. doi:10.1073/pnas.87.22.8707. PMID 2247438. Bibcode: 1990PNAS...87.8707R.
- "Generation and analysis of 280,000 human expressed sequence tags". Genome Research 6 (9): 807–28. September 1996. doi:10.1101/gr.6.9.807. PMID 8889549.
- "Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain". Molecular and Cellular Biology 19 (5): 3736–47. May 1999. doi:10.1128/mcb.19.5.3736. PMID 10207097.
- "Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells". The Biochemical Journal 345 (3): 535–41. February 2000. doi:10.1042/0264-6021:3450535. PMID 10642512.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. January 2006. doi:10.1101/gr.4039406. PMID 16344560.
External links
- HIVEP2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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