Biology:MYT1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene.[1][2][3]
Function
The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.[3]
Interactive pathway map
Interactions
MYT1 has been shown to interact with PIN1.[4]
References
- ↑ "Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene". Molecular and Cellular Biology 12 (12): 5632–9. Dec 1992. doi:10.1128/mcb.12.12.5632. PMID 1280325.
- ↑ "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". The Journal of Biological Chemistry 272 (35): 22300–6. Aug 1997. doi:10.1074/jbc.272.35.22300. PMID 9268380.
- ↑ 3.0 3.1 "Entrez Gene: MYT1 myelin transcription factor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4661.
- ↑ "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression". Journal of Cell Science 112 (19): 3361–71. Oct 1999. doi:10.1242/jcs.112.19.3361. PMID 10504341.
Further reading
- "Plasticity in the adult human oligodendrocyte lineage". The Journal of Neuroscience 14 (8): 4571–87. Aug 1994. doi:10.1523/JNEUROSCI.14-08-04571.1994. PMID 7519254.
- "Expression of myelin transcription factor I (MyTI), a "zinc-finger" DNA-binding protein, in developing oligodendrocytes". Glia 14 (4): 303–21. Aug 1995. doi:10.1002/glia.440140407. PMID 8530187.
- "The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex". Molecular and Cellular Biology 17 (2): 571–83. Feb 1997. doi:10.1128/mcb.17.2.571. PMID 9001210.
- "Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system". Journal of Neuroscience Research 50 (2): 272–90. Oct 1997. doi:10.1002/(SICI)1097-4547(19971015)50:2<272::AID-JNR16>3.0.CO;2-A. PMID 9373037. https://zenodo.org/record/1235486.
- "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 5 (6): 355–64. Dec 1998. doi:10.1093/dnares/5.6.355. PMID 10048485.
- "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 6 (3): 197–205. Jun 1999. doi:10.1093/dnares/6.3.197. PMID 10470851.
- "Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia". Brain Research. Developmental Brain Research 140 (1): 85–92. Jan 2003. doi:10.1016/S0165-3806(02)00585-0. PMID 12524179.
- "Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells". Molecular and Cellular Neurosciences 25 (1): 111–23. Jan 2004. doi:10.1016/j.mcn.2003.10.001. PMID 14962745.
- "Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS". Glia 55 (7): 687–97. May 2007. doi:10.1002/glia.20492. PMID 17330875.
External links
- MYT1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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