Biology:FOXH1
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Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.[1][2]
Function
FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.[2]
FoxH1 is a transcription factor that contains a conserved function in chordates. FoxH1, acts in combination with other transcription factors, as a critical element of node formation in early embryo development. Specifically, FoxH1 plays a role in anterior/posterior determination during gastrulation. By the third week of gestation, cells of the splanchnic mesoderm have migrated to the superior end of the embryo to form the cardiac crescent. The cardiac crescent forms two heart fields; primary heart field and the secondary heart field. At this point in development, the two heart fields fuse to form a primitive, single-chambered heart referred to as the primary myocardium. The secondary (anterior) heart field of these cardiac crescent cells will give rise to the outflow tract and the right ventricle of the mature heart. A model lacking FoxH1 will form a primary myocardium, undergo some amount of looping, but have undefined right ventricles and outflow tracts.
Interactions
FOXH1 has been shown to interact with DRAP1[3] and Mothers against decapentaplegic homolog 2.[4][5][6][7][8]
See also
References
- · Slagle CE, Aoki T, Burdine RD. Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin. PLoS Genet. 2011;7(5):e1002072. doi:10.1371/journal.pgen.1002072
- Hoodless PA, Pye M, Chazaud C, et al. FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev. 2001;15(10):1257-1271. doi:10.1101/gad.881501
- · von Both I, Silvestri C, Erdemir T, et al. Foxh1 is essential for development of the anterior heart field. Dev Cell. 2004;7(3):331-345. doi:10.1016/j.devcel.2004.07.023
- ↑ "Characterization of human FAST-1, a TGF beta and activin signal transducer". Molecular Cell 2 (1): 121–127. July 1998. doi:10.1016/S1097-2765(00)80120-3. PMID 9702198.
- ↑ 2.0 2.1 "Entrez Gene: FOXH1 forkhead box H1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8928.
- ↑ "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science 298 (5600): 1996–1999. December 2002. doi:10.1126/science.1073405. PMID 12471260. Bibcode: 2002Sci...298.1996I.
- ↑ "A Smad transcriptional corepressor". Cell 97 (1): 29–39. April 1999. doi:10.1016/S0092-8674(00)80712-6. PMID 10199400.
- ↑ "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Molecular and Cellular Biology 19 (1): 424–430. January 1999. doi:10.1128/MCB.19.1.424. PMID 9858566.
- ↑ "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes & Development 11 (23): 3157–3167. December 1997. doi:10.1101/gad.11.23.3157. PMID 9389648.
- ↑ "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Molecular and Cellular Biology 20 (17): 6201–6211. September 2000. doi:10.1128/MCB.20.17.6201-6211.2000. PMID 10938097.
- ↑ "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature 389 (6646): 85–89. September 1997. doi:10.1038/38008. PMID 9288972. Bibcode: 1997Natur.389...85C.
Further reading
- "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature 389 (6646): 85–89. September 1997. doi:10.1038/38008. PMID 9288972. Bibcode: 1997Natur.389...85C.
- "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes & Development 11 (23): 3157–3167. December 1997. doi:10.1101/gad.11.23.3157. PMID 9389648.
- "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Molecular and Cellular Biology 19 (1): 424–430. January 1999. doi:10.1128/MCB.19.1.424. PMID 9858566.
- "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Molecular and Cellular Biology 20 (17): 6201–6211. September 2000. doi:10.1128/MCB.20.17.6201-6211.2000. PMID 10938097.
- "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–1795. November 2000. doi:10.1101/gr.143000. PMID 11076863.
- "c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity". Proceedings of the National Academy of Sciences of the United States of America 98 (11): 6198–6203. May 2001. doi:10.1073/pnas.101579798. PMID 11371641. Bibcode: 2001PNAS...98.6198P.
- "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science 298 (5600): 1996–1999. December 2002. doi:10.1126/science.1073405. PMID 12471260. Bibcode: 2002Sci...298.1996I.
- "Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation". Cell 117 (2): 211–223. April 2004. doi:10.1016/S0092-8674(04)00298-3. PMID 15084259.
- "Foxh1 is essential for development of the anterior heart field". Developmental Cell 7 (3): 331–345. September 2004. doi:10.1016/j.devcel.2004.07.023. PMID 15363409.
- "Expression of the FAST-1 transcription factor in coronary artery transplant vasculopathy and activated vascular smooth muscle cells". The Journal of Heart and Lung Transplantation 24 (3): 246–250. March 2005. doi:10.1016/j.healun.2004.01.015. PMID 15737749.
- "Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP". Oncogene 24 (24): 3864–3874. June 2005. doi:10.1038/sj.onc.1208556. PMID 15750622.
- "Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1". Biochemical and Biophysical Research Communications 333 (4): 1361–1369. August 2005. doi:10.1016/j.bbrc.2005.06.044. PMID 15982639.
- "Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor". The Journal of Biological Chemistry 280 (43): 36355–36363. October 2005. doi:10.1074/jbc.M506147200. PMID 16120611.
External links
- FOXH1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
![]() | Original source: https://en.wikipedia.org/wiki/FOXH1.
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