Biology:NFATC1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Nuclear factor of activated T-cells, cytoplasmic 1 is a protein that in humans is encoded by the NFATC1 gene.

Function

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as ciclosporin. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

Interactions

NFATC1 has been shown to interact with PIM1.

See also

• NFAT

Further reading

• "Transcription factors of the NFAT family: regulation and function". Annual Review of Immunology 15: 707–47. 1997. doi:10.1146/annurev.immunol.15.1.707. PMID 9143705. 
• "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell 96 (5): 611–4. Mar 1999. doi:10.1016/S0092-8674(00)80571-1. PMID 10089876. 
• "NFAT: ubiquitous regulator of cell differentiation and adaptation". The Journal of Cell Biology 156 (5): 771–4. Mar 2002. doi:10.1083/jcb.200111073. PMID 11877454. 
• "HIV/SIV escape from immune surveillance: focus on Nef". Current HIV Research 2 (2): 141–51. Apr 2004. doi:10.2174/1570162043484924. PMID 15078178. 
• "Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp". Cytogenetics and Cell Genetics 68 (3–4): 185–91. 1995. doi:10.1159/000133910. PMID 7842733. 
• "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity". European Journal of Immunology 24 (11): 2646–52. Nov 1994. doi:10.1002/eji.1830241112. PMID 7957556. 
• "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif". Biochemical and Biophysical Research Communications 205 (1): 467–74. Nov 1994. doi:10.1006/bbrc.1994.2689. PMID 7999066. 
• "Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc". The Journal of Biological Chemistry 271 (34): 20914–21. Aug 1996. doi:10.1074/jbc.271.34.20914. PMID 8702849. 
• "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering". European Journal of Immunology 26 (9): 2181–8. Sep 1996. doi:10.1002/eji.1830260933. PMID 8814265. 
• "Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3". Science 275 (5308): 1930–4. Mar 1997. doi:10.1126/science.275.5308.1930. PMID 9072970. 
• "The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells". Immunity 6 (3): 235–44. Mar 1997. doi:10.1016/S1074-7613(00)80326-X. PMID 9075924. 
• "Solution structure of the core NFATC1/DNA complex". Cell 92 (5): 687–96. Mar 1998. doi:10.1016/S0092-8674(00)81136-8. PMID 9506523. 
• "Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells". Cell 95 (5): 595–604. Nov 1998. doi:10.1016/S0092-8674(00)81630-X. PMID 9845362. 
• "Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells". Immunity 10 (2): 261–9. Feb 1999. doi:10.1016/S1074-7613(00)80026-6. PMID 10072078. 
• "Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes". Journal of Immunology 162 (12): 7294–301. Jun 1999. doi:10.4049/jimmunol.162.12.7294. PMID 10358178. 
• "The Nef protein of HIV-1 associates with rafts and primes T cells for activation". Proceedings of the National Academy of Sciences of the United States of America 97 (1): 394–9. Jan 2000. doi:10.1073/pnas.97.1.394. PMID 10618429. Bibcode: 2000PNAS...97..394W. 
• "Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization". The Journal of Biological Chemistry 275 (5): 3543–51. Feb 2000. doi:10.1074/jbc.275.5.3543. PMID 10652349. 

External links

• NFATC1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.