Biology:SOX4
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.[1][2][3]
Function
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.[3]
Sox4 is expressed in lymphocytes (B and T) and is required for B lymphocyte development.[4]
Clinical significance
A genomic region close to the SOX4 gene has been associated with endometrial cancer development.[5][6]
Interactions
SOX4 has been shown to interact with SDCBP.[7]
See also
References
- ↑ "Characterization and mapping of the human SOX4 gene". Mammalian Genome 4 (10): 577–84. January 1994. doi:10.1007/BF00361388. PMID 8268656.
- ↑ "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3". Cytogenetics and Cell Genetics 81 (3–4): 294–5. October 1998. doi:10.1159/000015052. PMID 9730625.
- ↑ 3.0 3.1 "Entrez Gene: SOX4 SRY (sex determining region Y)-box 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6659.
- ↑ "The roles of transcription factors in B lymphocyte commitment, development, and transformation". Journal of Leukocyte Biology 75 (6): 973–81. June 2004. doi:10.1189/jlb.1103554. PMID 14982952.
- ↑ "Identification of nine new susceptibility loci for endometrial cancer" (in En). Nature Communications 9 (1): 3166. August 2018. doi:10.1038/s41467-018-05427-7. PMID 30093612. Bibcode: 2018NatCo...9.3166O.
- ↑ "GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer". Human Molecular Genetics 25 (12): 2612–2620. June 2016. doi:10.1093/hmg/ddw092. PMID 27008869.
- ↑ "Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein". Science 293 (5532): 1136–8. August 2001. doi:10.1126/science.1059157. PMID 11498591.
Further reading
- "Pairing SOX off: with partners in the regulation of embryonic development". Trends in Genetics 16 (4): 182–7. April 2000. doi:10.1016/S0168-9525(99)01955-1. PMID 10729834.
- "Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators". Developmental Biology 227 (2): 239–55. November 2000. doi:10.1006/dbio.2000.9883. PMID 11071752.
- "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Current Opinion in Genetics & Development 12 (4): 441–6. August 2002. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.
- "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Developmental Cell 3 (2): 167–70. August 2002. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
- "A conserved family of genes related to the testis determining gene, SRY". Nucleic Acids Research 20 (11): 2887. June 1992. doi:10.1093/nar/20.11.2887. PMID 1614875.
- "The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer". The Journal of Biological Chemistry 270 (13): 7515–22. March 1995. doi:10.1074/jbc.270.13.7515. PMID 7706298.
- "Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes". The EMBO Journal 12 (10): 3847–54. October 1993. doi:10.1002/j.1460-2075.1993.tb06063.x. PMID 8404853.
- "Solution structure of the sequence-specific HMG box of the lymphocyte transcriptional activator Sox-4". The Journal of Biological Chemistry 270 (51): 30516–24. December 1995. doi:10.1074/jbc.270.51.30516. PMID 8530483.
- "Identification of cDNAs for Sox-4, an HMG-Box protein, and a novel human homolog of yeast splicing factor SSF-1 differentially regulated during apoptosis induced by prostaglandin A2/delta12-PGJ2 in Hep3B cells". Biochemical and Biophysical Research Communications 260 (1): 216–21. June 1999. doi:10.1006/bbrc.1999.0856. PMID 10381369.
- "Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs". The Journal of Biological Chemistry 275 (35): 27266–73. September 2000. doi:10.1074/jbc.M004102200. PMID 10867006.
- "Sox-4 messenger RNA is expressed in the embryonic growth plate and regulated via the parathyroid hormone/parathyroid hormone-related protein receptor in osteoblast-like cells". Journal of Bone and Mineral Research 15 (12): 2402–12. December 2000. doi:10.1359/jbmr.2000.15.12.2402. PMID 11127205.
- "Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein". Science 293 (5532): 1136–8. August 2001. doi:10.1126/science.1059157. PMID 11498591.
- "Differential expression of SOX4 and SOX11 in medulloblastoma". Journal of Neuro-Oncology 57 (3): 201–14. May 2002. doi:10.1023/A:1015773818302. PMID 12125983.
- "Sox-4 is a positive regulator of Hep3B and HepG2 cells' apoptosis induced by prostaglandin (PG)A(2) and delta(12)-PGJ(2)". Experimental & Molecular Medicine 34 (3): 243–9. July 2002. doi:10.1038/emm.2002.34. PMID 12216117.
External links
- SOX4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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