Biology:KLF5
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.[1][2]
Function
This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.[2]
Interactions
KLF5 has been shown to interact with Protein SET.[3]
See also
References
- ↑ "cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2". Nucleic Acids Research 21 (7): 1527–32. Apr 1993. doi:10.1093/nar/21.7.1527. PMID 8479902.
- ↑ 2.0 2.1 "Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=688.
- ↑ "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology 23 (23): 8528–41. Dec 2003. doi:10.1128/MCB.23.23.8528-8541.2003. PMID 14612398.
Further reading
- "Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation". Cell Research 15 (2): 92–6. Feb 2005. doi:10.1038/sj.cr.7290271. PMID 15740636.
- "Significance of the transcription factor KLF5 in cardiovascular remodeling". Journal of Thrombosis and Haemostasis 3 (8): 1569–76. Aug 2005. doi:10.1111/j.1538-7836.2005.01366.x. PMID 16102021.
- "The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology". BioEssays 29 (6): 549–57. Jun 2007. doi:10.1002/bies.20581. PMID 17508399.
- "Transcriptional activation domain of human BTEB2, a GC box-binding factor". Journal of Biochemistry 121 (2): 389–96. Feb 1997. doi:10.1093/oxfordjournals.jbchem.a021600. PMID 9089417.
- "A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells". Nucleic Acids Research 27 (5): 1263–70. Mar 1999. doi:10.1093/nar/27.5.1263. PMID 9973612.
- "Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter". Nucleic Acids Research 27 (24): 4807–15. Dec 1999. doi:10.1093/nar/27.24.4807. PMID 10572182.
- "Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells: analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis". Circulation 102 (20): 2528–34. Nov 2000. doi:10.1161/01.cir.102.20.2528. PMID 11076828.
- "Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferation". The Journal of Biological Chemistry 276 (10): 6897–900. Mar 2001. doi:10.1074/jbc.C000870200. PMID 11152667.
- "Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene". Nucleic Acids Research 30 (13): 2736–41. Jul 2002. doi:10.1093/nar/gkf400. PMID 12087155.
- "Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling". Nature Medicine 8 (8): 856–63. Aug 2002. doi:10.1038/nm738. PMID 12101409.
- "Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles". European Journal of Cell Biology 81 (6): 323–34. Jun 2002. doi:10.1078/0171-9335-00257. PMID 12113473.
- "A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer". Oncogene 21 (43): 6567–72. Sep 2002. doi:10.1038/sj.onc.1205817. PMID 12242654.
- "Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs". Blood 101 (11): 4492–9. Jun 2003. doi:10.1182/blood-2002-08-2579. PMID 12576331.
- "KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer". The Prostate 55 (2): 81–8. May 2003. doi:10.1002/pros.10205. PMID 12661032.
- "Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function". Nucleic Acids Research 31 (8): 2196–208. Apr 2003. doi:10.1093/nar/gkg310. PMID 12682370.
- "Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer". Biochemical and Biophysical Research Communications 308 (2): 251–6. Aug 2003. doi:10.1016/S0006-291X(03)01356-1. PMID 12901861.
- "Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB". The Journal of Biological Chemistry 279 (1): 70–6. Jan 2004. doi:10.1074/jbc.M306621200. PMID 14573617.
- "Immunohistochemical study of surgically excised choroidal neovascular membranes". The Journal of International Medical Research 31 (5): 402–6. 2004. doi:10.1177/147323000303100507. PMID 14587307.
External links
- KLF5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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