Biology:BATF (gene)
 Generic protein structure example |
Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a protein which in humans is encoded by the BATF gene.[1][2][3]
Function
The protein encoded by this gene is a nuclear basic leucine zipper (bZIP) protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events.[3]
Mice without the BATF gene (BATF knockout mice) lacked a type of inflammatory immune cell (Th17) and were resistant to conditions that normally induces an autoimmune condition similar to multiple sclerosis.[4]
Interactions
BATF (gene) has been shown to interact with IFI35.[5]
References
- ↑ "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family". Oncogene 11 (11): 2255–65. December 1995. PMID 8570175.
- ↑ "SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes". Biochem. Biophys. Res. Commun. 222 (1): 164–70. May 1996. doi:10.1006/bbrc.1996.0700. PMID 8630063.
- ↑ 3.0 3.1 "Entrez Gene: BATF basic leucine zipper transcription factor, ATF-like". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10538.
- ↑ "The AP-1 transcription factor Batf controls TH17 differentiation". Nature 460 (7253): 405–9. July 2009. doi:10.1038/nature08114. PMID 19578362. Bibcode: 2009Natur.460..405S.
- "Gene regulates immune cells' ability to harm the body". EurekAlert! (Press release). 2009-07-16.
- ↑ "IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors". Biochem. Biophys. Res. Commun. 229 (1): 316–22. 1996. doi:10.1006/bbrc.1996.1799. PMID 8954125.
Further reading
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation". Biochem. J. 374 (Pt 2): 423–31. 2003. doi:10.1042/BJ20030455. PMID 12809553.
- "EBNA2 and Activated Notch Induce Expression of BATF". J. Virol. 77 (10): 6029–40. 2003. doi:10.1128/JVI.77.10.6029-6040.2003. PMID 12719594.
- "BATF transgenic mice reveal a role for activator protein-1 in NKT cell development". J. Immunol. 170 (5): 2417–26. 2003. doi:10.4049/jimmunol.170.5.2417. PMID 12594265.
- "B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos". Oncogene 19 (14): 1752–63. 2000. doi:10.1038/sj.onc.1203491. PMID 10777209.
- "Genomic organization of human B-ATF, a target for regulation by EBV and HTLV-1". Mamm. Genome 9 (10): 849–52. 1998. doi:10.1007/s003359900881. PMID 9745044.
- "IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors". Biochem. Biophys. Res. Commun. 229 (1): 316–22. 1997. doi:10.1006/bbrc.1996.1799. PMID 8954125.
- "SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes". Biochem. Biophys. Res. Commun. 222 (1): 164–70. 1996. doi:10.1006/bbrc.1996.0700. PMID 8630063.
- "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family". Oncogene 11 (11): 2255–65. 1996. PMID 8570175.
External links
- BATF+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- FactorBook BATF
- Human BATF genome location and BATF gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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