Biology:BACH2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Transcription regulator protein BACH2 (broad complex-tramtrack-bric a brac and Cap'n'collar homology 2) is a protein that in humans is encoded by the BACH2 gene.[1][2][3] It contains a BTB/POZ domain at its N-terminus which forms a disulphide-linked dimer [4] and a bZip Maf domain at the C-terminus.
References
- ↑ "Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15". Oncogene 19 (33): 3739–49. August 2000. doi:10.1038/sj.onc.1203716. PMID 10949928.
- ↑ "B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs". Blood 102 (9): 3317–22. November 2003. doi:10.1182/blood-2002-12-3656. PMID 12829606.
- ↑ "Entrez Gene: BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60468.
- ↑ "The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond". Acta Crystallographica Section D 68 (Pt 1): 26–34. January 2012. doi:10.1107/S0907444911048335. PMID 22194330. Bibcode: 2012AcCrD..68...26R. http://eprints.whiterose.ac.uk/79622/1/The%20Structure%20of%20teh%20Bach2%20POZ-domain%20Dimer%20Reveals%20an%20Intersubunit%20Disulphide%20Bond.pdf.
Further reading
- "Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site". Molecular and Cellular Biology 16 (11): 6083–95. November 1996. doi:10.1128/mcb.16.11.6083. PMID 8887638.
- "A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain". Molecular and Cellular Biology 20 (5): 1733–46. March 2000. doi:10.1128/MCB.20.5.1733-1746.2000. PMID 10669750.
- "Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element". The Journal of Biological Chemistry 275 (20): 15370–6. May 2000. doi:10.1074/jbc.275.20.15370. PMID 10809773.
- "Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene". Genes, Chromosomes & Cancer 32 (4): 353–63. December 2001. doi:10.1002/gcc.1200. PMID 11746976.
- "Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies". The Journal of Biological Chemistry 277 (23): 20724–33. June 2002. doi:10.1074/jbc.M112003200. PMID 11923289.
- "Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) induces loss of BACH2 expression". The American Journal of Pathology 164 (3): 967–74. March 2004. doi:10.1016/S0002-9440(10)63184-7. PMID 14982850.
- "Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2". Molecular and Cellular Biology 24 (8): 3473–84. April 2004. doi:10.1128/MCB.24.8.3473-3484.2004. PMID 15060166.
- "Differentially androgen-modulated genes in ovarian epithelial cells from BRCA mutation carriers and control patients predict ovarian cancer survival and disease progression". Oncogene 26 (2): 198–214. January 2007. doi:10.1038/sj.onc.1209773. PMID 16832351.
- "Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1". Blood 109 (3): 1211–9. February 2007. doi:10.1182/blood-2005-12-040972. PMID 17018862.
- "Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells". Genes, Chromosomes & Cancer 46 (1): 67–74. January 2007. doi:10.1002/gcc.20390. PMID 17044046.
- "Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy". The Journal of Infectious Diseases 195 (5): 716–25. March 2007. doi:10.1086/510915. PMID 17262715.
- "Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression". Journal of Biochemistry 141 (5): 719–27. May 2007. doi:10.1093/jb/mvm073. PMID 17383980.
External links
- BACH2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human BACH2 genome location and BACH2 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: Q9BYV9 (Transcription regulator protein BACH2) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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