Biology:TAF2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Transcription initiation factor TFIID subunit 2 is a protein that in humans is encoded by the TAF2 gene.[1][2][3]
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators.[3]
References
- ↑ "Novel cofactors and TFIIA mediate functional core promoter selectivity by the human TAFII150-containing TFIID complex". Mol Cell Biol 18 (11): 6571–83. Nov 1998. doi:10.1128/mcb.18.11.6571. PMID 9774672.
- ↑ "CIF150, a human cofactor for transcription factor IID-dependent initiator function". Mol Cell Biol 18 (1): 233–9. Jan 1998. doi:10.1128/mcb.18.1.233. PMID 9418870.
- ↑ 3.0 3.1 "Entrez Gene: TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6873.
Further reading
- "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits.". Science 266 (5193): 1966–72. 1995. doi:10.1126/science.7801123. PMID 7801123.
- "Novel mechanism and factor for regulation by HIV-1 Tat.". EMBO J. 14 (2): 321–8. 1995. doi:10.1002/j.1460-2075.1995.tb07006.x. PMID 7835343.
- "A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro.". J. Biol. Chem. 270 (5): 2274–83. 1995. doi:10.1074/jbc.270.5.2274. PMID 7836461.
- "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function.". J. Virol. 68 (11): 7188–99. 1994. doi:10.1128/JVI.68.11.7188-7199.1994. PMID 7933101.
- "Direct interaction of human TFIID with the HIV-1 transactivator tat.". Nature 367 (6460): 295–9. 1994. doi:10.1038/367295a0. PMID 8121496. Bibcode: 1994Natur.367..295K.
- "Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro.". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (2): 128–38. 1996. doi:10.1097/00042560-199606010-00005. PMID 8680883.
- "Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly.". J. Virol. 70 (8): 5025–34. 1996. doi:10.1128/JVI.70.8.5025-5034.1996. PMID 8764009.
- "Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex.". J. Virol. 70 (8): 5503–10. 1996. doi:10.1128/JVI.70.8.5503-5510.1996. PMID 8764062.
- "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.". Science 274 (5287): 605–10. 1996. doi:10.1126/science.274.5287.605. PMID 8849451. Bibcode: 1996Sci...274..605Z.
- "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes.". J. Biol. Chem. 272 (11): 6951–8. 1997. doi:10.1074/jbc.272.11.6951. PMID 9054383.
- "A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID.". J. Biol. Chem. 273 (37): 23781–5. 1998. doi:10.1074/jbc.273.37.23781. PMID 9726987.
- "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.". J. Biol. Chem. 274 (26): 18285–9. 1999. doi:10.1074/jbc.274.26.18285. PMID 10373431.
- "Human transcription factor hTAF(II)150 (CIF150) is involved in transcriptional regulation of cell cycle progression.". Mol. Cell. Biol. 19 (8): 5548–56. 1999. doi:10.1128/mcb.19.8.5548. PMID 10409744.
- "DNA binding site selection by RNA polymerase II TAFs: a TAF(II)250-TAF(II)150 complex recognizes the initiator.". EMBO J. 18 (17): 4835–45. 1999. doi:10.1093/emboj/18.17.4835. PMID 10469661.
- "Identification and characterization of the potential promoter regions of 1031 kinds of human genes.". Genome Res. 11 (5): 677–84. 2001. doi:10.1101/gr.gr-1640r. PMID 11337467.
- "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation.". EMBO J. 20 (12): 3187–96. 2001. doi:10.1093/emboj/20.12.3187. PMID 11406595.
- "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.". Mol. Cell. Biol. 21 (20): 6782–95. 2001. doi:10.1128/MCB.21.20.6782-6795.2001. PMID 11564863.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
External links
- TAF2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: Q6P1X5 (Transcription initiation factor TFIID subunit 2) at the PDBe-KB.
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