Biology:MTF1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.

Function

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).

Further reading

• "A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene". The EMBO Journal 7 (12): 3763–70. Dec 1988. doi:10.1002/j.1460-2075.1988.tb03260.x. PMID 3208749. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "MRE-Binding transcription factor-1: weak zinc-binding finger domains 5 and 6 modulate the structure, affinity, and specificity of the metal-response element complex". Biochemistry 38 (39): 12915–25. Sep 1999. doi:10.1021/bi9913000. PMID 10504263. 
• "Novel responses of ZRF, a variant of human MTF-1, to in vivo treatment with heavy metals". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1492 (2–3): 330–40. Jul 2000. doi:10.1016/s0167-4781(00)00110-x. PMID 11004505. 
• "Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals". The Journal of Biological Chemistry 276 (27): 25487–95. Jul 2001. doi:10.1074/jbc.M009154200. PMID 11306562. 
• "Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription". The Journal of Biological Chemistry 277 (23): 20438–45. Jun 2002. doi:10.1074/jbc.M110631200. PMID 11923282. 
• "Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1". The Journal of Biological Chemistry 278 (28): 26216–26. Jul 2003. doi:10.1074/jbc.M302887200. PMID 12716893. 
• "Heat and heavy metal stress synergize to mediate transcriptional hyperactivation by metal-responsive transcription factor MTF-1". The Journal of Biological Chemistry 278 (34): 31879–83. Aug 2003. doi:10.1074/jbc.M302138200. PMID 12805380. 
• "A novel cysteine cluster in human metal-responsive transcription factor 1 is required for heavy metal-induced transcriptional activation in vivo". The Journal of Biological Chemistry 279 (6): 4515–22. Feb 2004. doi:10.1074/jbc.M308924200. PMID 14610091. 
• "Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison". Biological Chemistry 385 (7): 597–603. Jul 2004. doi:10.1515/BC.2004.074. PMID 15318808. 
• "Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors". Oncogene 24 (13): 2204–17. Mar 2005. doi:10.1038/sj.onc.1208206. PMID 15735762. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 

External links

• MTF1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.