Biology:MLX (gene)
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Max-like protein X is a protein that in humans is encoded by the MLX gene.[1][2]
Function
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[2]
Interactions
MLX (gene) has been shown to interact with MNT,[3][4] MXD1[3][4] and MLXIPL.[3]
MLX must dimerize with MondoA[5] or with MLXIPL (carbohydrate-responsive element-binding protein) to regulate target genes.[6]
References
- ↑ "TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor". Gene 181 (1–2): 7–11. November 1996. doi:10.1016/S0378-1119(96)00376-9. PMID 8973301.
- ↑ 2.0 2.1 "Entrez Gene: MLX MAX-like protein X". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6945.
- ↑ 3.0 3.1 3.2 "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics 10 (6): 617–27. March 2001. doi:10.1093/hmg/10.6.617. PMID 11230181.
- ↑ 4.0 4.1 "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene 19 (29): 3266–77. July 2000. doi:10.1038/sj.onc.1203634. PMID 10918583.
- ↑ "MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction". Molecular and Cellular Biology 35 (1): 101–110. 2015. doi:10.1128/MCB.00636-14. PMID 25332233.
- ↑ "Glucose-Sensing Transcription Factor MondoA/ChREBP as Targets for Type 2 Diabetes: Opportunities and Challenges". International Journal of Molecular Sciences 20 (20): E5132. 2019. doi:10.3390/ijms20205132. PMID 31623194.
Further reading
- "Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21". Genomics 28 (3): 530–42. August 1995. doi:10.1006/geno.1995.1185. PMID 7490091.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. September 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Generation and analysis of 280,000 human expressed sequence tags". Genome Research 6 (9): 807–28. September 1996. doi:10.1101/gr.6.9.807. PMID 8889549.
- "Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors". The Journal of Biological Chemistry 274 (51): 36344–50. December 1999. doi:10.1074/jbc.274.51.36344. PMID 10593926.
- "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene 19 (29): 3266–77. July 2000. doi:10.1038/sj.onc.1203634. PMID 10918583.
- "MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network". Molecular and Cellular Biology 20 (23): 8845–54. December 2000. doi:10.1128/MCB.20.23.8845-8854.2000. PMID 11073985.
- "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics 10 (6): 617–27. March 2001. doi:10.1093/hmg/10.6.617. PMID 11230181.
- "A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex". Molecular and Cellular Biology 22 (24): 8514–26. December 2002. doi:10.1128/MCB.22.24.8514-8526.2002. PMID 12446771.
- "The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3". Human Molecular Genetics 13 (14): 1505–14. July 2004. doi:10.1093/hmg/ddh163. PMID 15163635.
- "Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes". The Journal of Biological Chemistry 280 (12): 12019–27. March 2005. doi:10.1074/jbc.M413063200. PMID 15664996.
- "MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis". Molecular and Cellular Biology 26 (13): 4863–71. July 2006. doi:10.1128/MCB.00657-05. PMID 16782875.
External links
- MLX+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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