Biology:Ets variant 5
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
| ets variant gene 5 (ets-related molecule) | |
|---|---|
| Identifiers | |
| Symbol | ETV5 |
| Alt. symbols | ERM |
| NCBI gene | 2119 |
| HGNC | 3494 |
| OMIM | 601600 |
| RefSeq | NM_004454 |
| UniProt | P41161 |
| Other data | |
| Locus | Chr. 3 q28 |
Ets variant 5 (ETV5) (also named ERM transcription factor) is a transcription factor that in humans is encoded by the ETV5 gene.[1] It is generated in Sertoli cells, which are found in the testes and play a crucial role in spermatogenesis. Its ortholog has been linked to both obesity and bipolar disorder.[2]
References
- ↑ "Entrez Gene: Ets variant 5". https://www.ncbi.nlm.nih.gov/gene/2119.
- ↑ "The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder". PLOS Genetics 12 (6): e1006104. June 2016. doi:10.1371/journal.pgen.1006104. PMID 27280443.
Further reading
- "Expression of the Ets transcription factor Erm is regulated through a conventional PKC signaling pathway in the Molt4 lymphoblastic cell line". FEBS Letters 579 (1): 66–70. January 2005. doi:10.1016/j.febslet.2004.11.052. PMID 15620692.
- "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 153B (2): 695–9. March 2010. doi:10.1002/ajmg.b.31026. PMID 19746409.
- "ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas". Oncogene 31 (45): 4778–88. November 2012. doi:10.1038/onc.2011.632. PMID 22266854.
- "Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells". The Journal of Biological Chemistry 276 (44): 40417–23. November 2001. doi:10.1074/jbc.M104765200. PMID 11509567.
- "Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes". Blood 99 (12): 4554–61. June 2002. doi:10.1182/blood.V99.12.4554. PMID 12036888.
- "Prognostic value of ERM gene expression in human primary breast cancers". Clinical Cancer Research 10 (21): 7297–303. November 2004. doi:10.1158/1078-0432.CCR-04-0593. PMID 15534105.
- "Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma". Human Pathology 42 (1): 57–67. January 2011. doi:10.1016/j.humpath.2010.01.025. PMID 20970160.
- "Proteomic approach to ETV5 during endometrial carcinoma invasion reveals a link to oxidative stress". Carcinogenesis 30 (8): 1288–97. August 2009. doi:10.1093/carcin/bgp119. PMID 19443906.
- "Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese". The Journal of Clinical Endocrinology and Metabolism 95 (5): 2418–25. May 2010. doi:10.1210/jc.2009-2077. PMID 20215397.
External links
- ERM+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- ETV5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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