Biology:COUP-TFI
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Short description: Protein found in humans
 Generic protein structure example |
COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene.[1][2] This protein is a member of nuclear hormone receptor family of steroid hormone receptors.
Function
Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription.[3][4] COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.[5]
Interactions
COUP-TFI has been shown to interact with:
Clinical
Mutations in this gene have been associated with Bosch-Boonstra-Schaaf optic atrophy syndrome.[9]
References
- ↑ "Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7025.
- ↑ "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes". Genomics 29 (1): 240–6. Sep 1995. doi:10.1006/geno.1995.1237. PMID 8530078.
- ↑ "Identification of two factors required for transcription of the ovalbumin gene". Molecular and Cellular Biology 6 (12): 4259–67. Dec 1986. doi:10.1128/MCB.6.12.4259. PMID 3796602.
- ↑ "Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell 50 (5): 701–9. Aug 1987. doi:10.1016/0092-8674(87)90328-X. PMID 3040258.
- ↑ "Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age". Endocrine Reviews 18 (2): 229–40. Apr 1997. doi:10.1210/edrv.18.2.0294. PMID 9101138.
- ↑ 6.0 6.1 "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". The Journal of Biological Chemistry 275 (14): 10315–22. Apr 2000. doi:10.1074/jbc.275.14.10315. PMID 10744719.
- ↑ "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Molecular and Cellular Biology 19 (5): 3383–94. May 1999. doi:10.1128/mcb.19.5.3383. PMID 10207062.
- ↑ "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK". The EMBO Journal 21 (13): 3443–53. Jul 2002. doi:10.1093/emboj/cdf344. PMID 12093745.
- ↑ Hobbs MM, Wolters WC, Rayapati AO (2020) Bosch-Boonstra-Schaaf optic atrophy syndrome presenting as new-onset psychosis in a 32-year-old man: A case report and literature review. J Psychiatr Pract 26(1):58-62
External links
- Human NR2F1 genome location and NR2F1 gene details page in the UCSC Genome Browser.
- Human NR2F2 genome location and NR2F2 gene details page in the UCSC Genome Browser.
Further reading
- "Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling". Proceedings of the National Academy of Sciences of the United States of America 89 (4): 1448–52. Feb 1992. doi:10.1073/pnas.89.4.1448. PMID 1311101. Bibcode: 1992PNAS...89.1448K.
- "Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein". Molecular Endocrinology 6 (9): 1468–78. Sep 1992. doi:10.1210/mend.6.9.1331778. PMID 1331778.
- "Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II)". The Journal of Biological Chemistry 267 (25): 17617–23. Sep 1992. doi:10.1016/S0021-9258(19)37087-5. PMID 1517211.
- "COUP transcription factor is a member of the steroid receptor superfamily". Nature 340 (6229): 163–6. Jul 1989. doi:10.1038/340163a0. PMID 2739739. Bibcode: 1989Natur.340..163W.
- "Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other". Nucleic Acids Research 16 (23): 11057–74. Dec 1988. doi:10.1093/nar/16.23.11057. PMID 2905047.
- "Chicken ovalbumin upstream promoter transcription factor, a transcriptional activator of HIV-1 gene expression in human brain cells". The Journal of Biological Chemistry 271 (38): 23572–6. Sep 1996. doi:10.1074/jbc.271.38.23572. PMID 8798567.
- "COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells". The Journal of Biological Chemistry 272 (49): 31149–55. Dec 1997. doi:10.1074/jbc.272.49.31149. PMID 9388268.
- "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Molecular and Cellular Biology 19 (5): 3383–94. May 1999. doi:10.1128/mcb.19.5.3383. PMID 10207062.
- "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1". Archives of Biochemistry and Biophysics 373 (1): 163–74. Jan 2000. doi:10.1006/abbi.1999.1552. PMID 10620335.
- "The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells". The Journal of Biological Chemistry 275 (4): 2654–60. Jan 2000. doi:10.1074/jbc.275.4.2654. PMID 10644726.
- "Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene". The Journal of Biological Chemistry 275 (5): 3446–54. Feb 2000. doi:10.1074/jbc.275.5.3446. PMID 10652338.
- "Subcellular trafficking of the nuclear receptor COUP-TF in the early embryonic cell cycle". Developmental Biology 218 (2): 284–98. Feb 2000. doi:10.1006/dbio.1999.9456. PMID 10656770.
- "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". The Journal of Biological Chemistry 275 (14): 10315–22. Apr 2000. doi:10.1074/jbc.275.14.10315. PMID 10744719.
- "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions". Molecular Endocrinology 14 (10): 1627–48. Oct 2000. doi:10.1210/me.14.10.1627. PMID 11043578.
- "Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors". Archives of Biochemistry and Biophysics 398 (1): 79–86. Feb 2002. doi:10.1006/abbi.2001.2713. PMID 11811951.
- "Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor". The Journal of Biological Chemistry 277 (24): 21414–22. Jun 2002. doi:10.1074/jbc.M201885200. PMID 11934895.
- "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK". The EMBO Journal 21 (13): 3443–53. Jul 2002. doi:10.1093/emboj/cdf344. PMID 12093745.
- "Distinct modes of regulation of transcription of hepatitis B virus by the nuclear receptors HNF4alpha and COUP-TF1". Journal of Virology 77 (4): 2489–99. Feb 2003. doi:10.1128/JVI.77.4.2489-2499.2003. PMID 12551987.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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