Biology:Sp4 transcription factor

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Transcription factor Sp4 is a protein that in humans is encoded by the SP4 gene.

Interactions

Sp4 transcription factor has been shown to interact with E2F1.

Further reading

• "The Sp-family of transcription factors". Gene 238 (2): 291–300. Oct 1999. doi:10.1016/S0378-1119(99)00357-1. PMID 10570957. 
• "Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3". The Journal of Biological Chemistry 270 (42): 24989–94. Oct 1995. doi:10.1074/jbc.270.42.24989. PMID 7559627. 
• "Human Sp4 transcription factor gene (SP4) maps to chromosome 7p15". Genomics 26 (3): 631–3. Apr 1995. doi:10.1016/0888-7543(95)80191-N. PMID 7607696. 
• "Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1". Nucleic Acids Research 22 (23): 4914–21. Nov 1994. doi:10.1093/nar/22.23.4914. PMID 7800480. 
• "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". Journal of Molecular Biology 293 (5): 1005–15. Nov 1999. doi:10.1006/jmbi.1999.3213. PMID 10547281. 
• "A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages". Cell 102 (5): 671–82. Sep 2000. doi:10.1016/S0092-8674(00)00089-1. PMID 11007485. 
• "Nrl and Sp nuclear proteins mediate transcription of rod-specific cGMP-phosphodiesterase beta-subunit gene: involvement of multiple response elements". The Journal of Biological Chemistry 276 (37): 34999–5007. Sep 2001. doi:10.1074/jbc.M103301200. PMID 11438531. 
• "The rod cGMP-phosphodiesterase beta-subunit promoter is a specific target for Sp4 and is not activated by other Sp proteins or CRX". The Journal of Biological Chemistry 277 (29): 25877–83. Jul 2002. doi:10.1074/jbc.M201407200. PMID 11943774. 
• "POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1". The Journal of Biological Chemistry 277 (30): 26761–8. Jul 2002. doi:10.1074/jbc.M202078200. PMID 12004059. 
• "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Molecular Vision 8: 196–204. Jun 2002. PMID 12107411. 
• "Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors". Nucleic Acids Research 31 (3): 1097–107. Feb 2003. doi:10.1093/nar/gkg192. PMID 12560508. 
• "Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins". Endocrinology 145 (12): 5774–85. Dec 2004. doi:10.1210/en.2004-0686. PMID 15345676. 
• "Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases". The Journal of Clinical Endocrinology and Metabolism 90 (6): 3479–90. Jun 2005. doi:10.1210/jc.2004-1962. PMID 15788387. 
• "Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins". Endocrinology 147 (7): 3285–95. Jul 2006. doi:10.1210/en.2006-0081. PMID 16574784. 
• "Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin with digenic disease". Molecular Vision 13: 287–92. 2007. PMID 17356515. 

External links

• Sp4+Transcription+Factor at the US National Library of Medicine Medical Subject Headings (MeSH)