Biology:GFI1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Zinc finger protein Gfi-1 is a transcriptional repressor that in humans is encoded by the GFI1 gene. It is important normal hematopoiesis.

Interactions

GFI1 has been shown to interact with PIAS3 and RUNX1T1.

Further reading

• "Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein". Mol. Cell. Biol. 13 (3): 1759–68. 1993. doi:10.1128/MCB.13.3.1759. PMID 8441411. 
• "Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor". Mol. Cell. Biol. 16 (8): 4024–34. 1996. doi:10.1128/MCB.16.8.4024. PMID 8754800. 
• "Cloning of the human Gfi-1 gene and its mapping to chromosome region 1p22". Oncogene 14 (8): 1003–5. 1997. doi:10.1038/sj.onc.1200910. PMID 9051000. 
• "The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3". EMBO J. 19 (21): 5845–55. 2000. doi:10.1093/emboj/19.21.5845. PMID 11060035. 
• "Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis". Blood 100 (8): 2769–77. 2002. doi:10.1182/blood-2002-01-0182. PMID 12351384. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2". Nat. Genet. 34 (3): 308–12. 2003. doi:10.1038/ng1170. PMID 12778173. 
• "Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism". J. Cell. Biochem. 89 (5): 1005–18. 2003. doi:10.1002/jcb.10548. PMID 12874834. 
• "Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells". Nucleic Acids Res. 32 (8): 2508–19. 2004. doi:10.1093/nar/gkh570. PMID 15131254. 
• "Identification of growth factor independent-1 (GFI1) as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells". Endocr. Relat. Cancer 12 (2): 351–65. 2005. doi:10.1677/erc.1.00920. PMID 15947108. 
• "Gfi1 Coordinates Epigenetic Repression of p21Cip/WAF1 by Recruitment of Histone Lysine Methyltransferase G9a and Histone Deacetylase 1". Mol. Cell. Biol. 25 (23): 10338–51. 2005. doi:10.1128/MCB.25.23.10338-10351.2005. PMID 16287849. 
• "Diminished proteasomal degradation results in accumulation of Gfi1 protein in monocytes". Blood 109 (1): 100–8. 2007. doi:10.1182/blood-2006-02-003590. PMID 16888099. 
• "Role of oncoprotein growth factor independent-1 (GFI1) in repression of 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1): a comparative analysis in human prostate cancer and kidney cells". J. Steroid Biochem. Mol. Biol. 103 (3–5): 742–6. 2007. doi:10.1016/j.jsbmb.2006.12.014. PMID 17207994. 
• "Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression". Oncogene 26 (24): 3541–50. 2007. doi:10.1038/sj.onc.1210140. PMID 17213822. 
• "Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPϵ gene". Blood 109 (10): 4181–90. 2007. doi:10.1182/blood-2005-05-022004. PMID 17244686. 
• "Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1". Blood 110 (9): 3128–35. 2007. doi:10.1182/blood-2006-11-058602. PMID 17646546. 

External links

• GFI1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.