Biology:FOSL1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.

Function

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.

Interactions

FOSL1 has been shown to interact with USF1 (human gene) and C-jun.

See also

• AP-1 (transcription factor)

Further reading

• "Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins". Brain Research. Brain Research Reviews 28 (3): 370–490. Dec 1998. doi:10.1016/S0165-0173(98)00018-6. PMID 9858769. 
• "Role and regulation of activator protein-1 in toxicant-induced responses of the lung". American Journal of Physiology. Lung Cellular and Molecular Physiology 283 (6): L1161–1178. Dec 2002. doi:10.1152/ajplung.00140.2002. PMID 12424143. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals". Journal of Virology 67 (12): 7001–7007. Dec 1993. doi:10.1128/JVI.67.12.7001-7007.1993. PMID 8230424. 
• "Reverse mapping of the gene encoding the human fos-related antigen-1 (fra-1) within chromosome band 11q13". Genomics 18 (1): 165. Oct 1993. doi:10.1006/geno.1993.1447. PMID 8276409. 
• "Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1)". Genomics 37 (3): 354–365. Nov 1996. doi:10.1006/geno.1996.0570. PMID 8938448. 
• "Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro". Nucleic Acids Research 25 (2): 311–317. Jan 1997. doi:10.1093/nar/25.2.311. PMID 9016559. 
• "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene 14 (17): 2091–2098. May 1997. doi:10.1038/sj.onc.1201046. PMID 9160889. 
• "A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13". Genome Research 7 (8): 835–842. Aug 1997. doi:10.1101/gr.7.8.835. PMID 9267807. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Expression of fos and jun genes in human skeletal muscle after exercise". The American Journal of Physiology 274 (1 Pt 1): C129–37. Jan 1998. doi:10.1152/ajpcell.1998.274.1.C129. PMID 9458721. 
• "Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition". Oncogene 19 (29): 3235–3244. Jul 2000. doi:10.1038/sj.onc.1203643. PMID 10918580. 
• "Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region". Biochemical and Biophysical Research Communications 289 (1): 25–33. Nov 2001. doi:10.1006/bbrc.2001.5929. PMID 11708771. 
• "Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1". The Journal of Biological Chemistry 277 (24): 21158–21166. Jun 2002. doi:10.1074/jbc.M112145200. PMID 11912197. 
• "Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin". International Journal of Cancer 101 (4): 301–310. Oct 2002. doi:10.1002/ijc.10630. PMID 12209953. 
• "A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers". The Biochemical Journal 369 (Pt 3): 485–496. Feb 2003. doi:10.1042/BJ20020707. PMID 12371906. 

External links

• FOSL1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook FOSL1

This article incorporates text from the United States National Library of Medicine, which is in the public domain.