Biology:MEIS1

Short description: Protein-coding gene in humans

Generic protein structure example

Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene.

Function

Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.

Interactions

MEIS1 has been shown to interact with PBX1 and HOXA9.

Further reading

• "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia". Leukemia & Lymphoma 39 (3–4): 241–56. Oct 2000. doi:10.3109/10428190009065824. PMID 11342305. 
• "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. Sep 1996. doi:10.1101/gr.6.9.791. PMID 8889548. 
• "Identification of a conserved family of Meis1-related homeobox genes". Genome Research 7 (2): 142–56. Feb 1997. doi:10.1101/gr.7.2.142. PMID 9049632. 
• "Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene". Genomics 43 (1): 99–103. Jul 1997. doi:10.1006/geno.1997.4766. PMID 9226379. 
• "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology 17 (11): 6448–58. Nov 1997. doi:10.1128/MCB.17.11.6448. PMID 9343407. 
• "Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1". Proceedings of the National Academy of Sciences of the United States of America 94 (26): 14553–8. Dec 1997. doi:10.1073/pnas.94.26.14553. PMID 9405651. Bibcode: 1997PNAS...9414553K. 
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998). "Toward a complete human genome sequence". Genome Research 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074. 
• "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology 19 (4): 3051–61. Apr 1999. doi:10.1128/MCB.19.4.3051. PMID 10082572. 
• "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology 19 (7): 5134–42. Jul 1999. doi:10.1128/MCB.19.7.5134. PMID 10373562. 
• "A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1". Nucleic Acids Research 27 (18): 3752–61. Sep 1999. doi:10.1093/nar/27.18.3752. PMID 10471746. 
• "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology 19 (11): 7577–88. Nov 1999. doi:10.1128/MCB.19.11.7577. PMID 10523646. 
• "The MEIS1 oncogene is highly expressed in neuroblastoma and amplified in cell line IMR32". Genomics 71 (2): 214–21. Jan 2001. doi:10.1006/geno.2000.6408. PMID 11161815. 
• "The homeodomain proteins PBX and MEIS1 are accessory factors that enhance thyroid hormone regulation of the malic enzyme gene in hepatocytes". The Journal of Biological Chemistry 276 (26): 23838–48. Jun 2001. doi:10.1074/jbc.M102166200. PMID 11331288. 
• "Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene". Blood 101 (12): 4748–56. Jun 2003. doi:10.1182/blood-2002-02-0380. PMID 12609849. 
• "Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization". Molecular and Cellular Biology 24 (2): 617–28. Jan 2004. doi:10.1128/MCB.24.2.617-628.2004. PMID 14701735. 
• "Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1". Molecular and Cellular Biology 24 (5): 1907–17. Mar 2004. doi:10.1128/MCB.24.5.1907-1917.2004. PMID 14966272. 

External links

• MEIS1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.