Biology:GABPB2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

GA-binding protein subunit beta-1 is a protein that in humans is encoded by the GABPB1 gene.

This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Further reading

• "Regional mapping of two subunits of transcription factor E4TF1 to human chromosome.". Jpn. J. Cancer Res. 86 (1): 10–2. 1995. doi:10.1111/j.1349-7006.1995.tb02981.x. PMID 7737900. 
• "Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain.". Mol. Cell. Biol. 15 (1): 102–11. 1995. doi:10.1128/MCB.15.1.102. PMID 7799916. 
• "Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters.". Genes Dev. 7 (3): 380–92. 1993. doi:10.1101/gad.7.3.380. PMID 8383622. 
• "cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs.". Mol. Cell. Biol. 13 (3): 1385–91. 1993. doi:10.1128/MCB.13.3.1385. PMID 8441384. 
• "Nuclear respiratory factors 1 and 2 utilize similar glutamine-containing clusters of hydrophobic residues to activate transcription.". Mol. Cell. Biol. 16 (10): 5708–16. 1996. doi:10.1128/mcb.16.10.5708. PMID 8816484. 
• "Functional domains of transcription factor hGABP beta1/E4TF1-53 required for nuclear localization and transcription activation.". Nucleic Acids Res. 24 (24): 4954–61. 1997. doi:10.1093/nar/24.24.4954. PMID 9016666. 
• "Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1.". Cancer Res. 57 (15): 3145–8. 1997. PMID 9242441. 
• "The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA.". Science 279 (5353): 1037–41. 1998. doi:10.1126/science.279.5353.1037. PMID 9461436. Bibcode: 1998Sci...279.1037B. 
• "Functional interactions of transcription factor human GA-binding protein subunits.". J. Biol. Chem. 273 (45): 29302–8. 1998. doi:10.1074/jbc.273.45.29302. PMID 9792629. 
• "Synergistic transcriptional activation by hGABP and select members of the activation transcription factor/cAMP response element-binding protein family.". J. Biol. Chem. 274 (50): 35475–82. 2000. doi:10.1074/jbc.274.50.35475. PMID 10585419. 
• "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP.". EMBO J. 19 (4): 683–90. 2000. doi:10.1093/emboj/19.4.683. PMID 10675337. 
• "YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors.". J. Biol. Chem. 277 (25): 22484–90. 2002. doi:10.1074/jbc.M203060200. PMID 11953439. 
• "Mutation of a nuclear respiratory factor 2 binding site in the 5' untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency.". Am. J. Hum. Genet. 71 (1): 14–21. 2002. doi:10.1086/341036. PMID 12016589. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• "Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor.". FEBS Lett. 580 (2): 669–76. 2006. doi:10.1016/j.febslet.2005.12.086. PMID 16412436. 
• "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 

External links

• GABPB2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: Q00420 (Mouse GA-binding protein subunit beta-1) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.