Biology:MYCL
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.[1][2]
MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.[3]
Interactions
MYCL1 has been shown to interact with MAX.[4][5]
References
- ↑ "Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization". Cytogenet Cell Genet 72 (2–3): 189–190. Jan 1997. doi:10.1159/000134185. PMID 8978772.
- ↑ "Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4610.
- ↑ "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. 1989. doi:10.1002/j.1460-2075.1989.tb03573.x. PMID 2548855.
- ↑ "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Science 251 (4998): 1211–1217. Mar 1991. doi:10.1126/science.2006410. PMID 2006410. Bibcode: 1991Sci...251.1211B.
- ↑ "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene 18 (15): 2489–2498. Apr 1999. doi:10.1038/sj.onc.1202611. PMID 10229200.
Further reading
- "Function and regulation of the transcription factors of the Myc/Max/Mad network". Gene 277 (1–2): 1–14. 2001. doi:10.1016/S0378-1119(01)00697-7. PMID 11602341.
- "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. 1989. doi:10.1002/j.1460-2075.1989.tb03573.x. PMID 2548855.
- "Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing". Mol. Cell. Biol. 8 (1): 186–95. 1988. doi:10.1128/mcb.8.1.186. PMID 2827002.
- "The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs". Mol. Cell. Biol. 8 (10): 4381–8. 1988. doi:10.1128/mcb.8.10.4381. PMID 3054516.
- "The human myc gene family: structure and activity of L-myc and an L-myc pseudogene". Genes Dev. 1 (10): 1311–1326. 1988. doi:10.1101/gad.1.10.1311. PMID 3322939.
- "Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10217–10221. 1995. doi:10.1073/pnas.92.22.10217. PMID 7479755. Bibcode: 1995PNAS...9210217A.
- "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene 18 (15): 2489–2498. 1999. doi:10.1038/sj.onc.1202611. PMID 10229200.
- "L-myc genotype is associated with different susceptibility to lung cancer in smokers". Jpn. J. Cancer Res. 93 (1): 1–5. 2002. doi:10.1111/j.1349-7006.2002.tb01193.x. PMID 11802801.
- "L-myc restriction fragment length polymorphism and histological pattern of invasion in lung adenocarcinoma". Oncol. Rep. 9 (2): 345–7. 2002. doi:10.3892/or.9.2.345. PMID 11836605.
- "Allelic deletions of Rb and L-myc in urine sediments from patients with bladder tumors or carcinoma in situ". Oncol. Rep. 9 (3): 551–5. 2002. doi:10.3892/or.9.3.551. PMID 11956626.
- "MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis". J. Cell. Mol. Med. 6 (2): 215–222. 2003. doi:10.1111/j.1582-4934.2002.tb00188.x. PMID 12169206.
- "Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas". Am. J. Pathol. 162 (5): 1603–10. 2003. doi:10.1016/S0002-9440(10)64294-0. PMID 12707044.
- "Allelic loss of a common microsatellite marker MYCL1: a useful prognostic factor of poor outcomes in colorectal cancer". Clin. Cancer Res. 10 (5): 1758–1763. 2004. doi:10.1158/1078-0432.CCR-0779-3. PMID 15014029.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival". Lung Cancer 55 (3): 271–277. 2007. doi:10.1016/j.lungcan.2006.10.023. PMID 17145094. https://air.unimi.it/bitstream/2434/25016/2/93-Ethnic%20differences%20in%20frequencies%20of%20gene%20Lung%20cancer.pdf.
External links
- MYCL1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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