Biology:TFAP2B

From HandWiki
Short description: Protein that in humans and is encoded by the TFAP2B gene


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Transcription factor AP-2 beta also known as AP2-beta is a protein that in humans is encoded by the TFAP2B gene.[1][2]

Function

AP-2 beta is a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor.[3]

Clinical significance

Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.[3]

References

  1. "Cloning and characterization of a second AP-2 transcription factor: AP-2 beta". Development 121 (9): 2779–88. 1 September 1995. doi:10.1242/dev.121.9.2779. PMID 7555706. 
  2. "Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors". Genomics 35 (1): 262–4. July 1996. doi:10.1006/geno.1996.0351. PMID 8661133. 
  3. 3.0 3.1 "Entrez Gene: transcription factor AP-2 beta (activating enhancer binding protein 2 beta)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7021. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.