Biology:ZNF300
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Short description: Human protein-coding gene
 Generic protein structure example |
Zinc finger protein 300 is a protein that in humans is encoded by the ZNF300 gene.[1][2] The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and a likely transcription factor.
It is antisense to the human gene, C16orf71, indicating possibility of regulated alternative expression.[3]
Clinical relevance
It is associated with Crohn's disease.[4]
References
- ↑ "Identification and functional analysis of a novel human KRAB/C2H2 zinc finger gene ZNF300". Biochim. Biophys. Acta 1676 (2): 203–209. January 2004. doi:10.1016/j.bbaexp.2003.11.011. PMID 14746915.
- ↑ "Entrez Gene: zinc finger protein 300". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91975.
- ↑ "AceView: Gene:C16orf71, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView.". https://www.ncbi.nlm.nih.gov/ieb/research/acembly/av.cgi?db=human&term=C16orf71&submit=Go.
- ↑ "Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease". Hum. Mol. Genet. 19 (9): 1828–1839. May 2010. doi:10.1093/hmg/ddq041. PMID 20106866. PMC 2850616. https://dash.harvard.edu/bitstream/handle/1/4706587/2850616.pdf?sequence=1.
Further reading
- "Genome-wide searching of rare genetic variants in WTCCC data.". Hum. Genet. 128 (3): 269–80. 2010. doi:10.1007/s00439-010-0849-9. PMID 20549515.
- "Identification of the DNA binding element of the human ZNF300 protein.". Cell. Mol. Biol. Lett. 13 (3): 391–403. 2008. doi:10.2478/s11658-008-0005-x. PMID 18350257.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60.". Leuk. Res. 34 (12): 1636–46. 2010. doi:10.1016/j.leukres.2010.04.009. PMID 20471086.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "ZNF300, a recently identified human transcription factor, activates the human IL-2Rβ promoter through the overlapping ZNF300/EGR1 binding site.". Cell. Mol. Biol. Lett. 15 (4): 530–40. 2010. doi:10.2478/s11658-010-0025-1. PMID 20585888.
- "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. 2005. doi:10.1007/s00335-005-0075-2. PMID 16341674.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Molecular cloning and characterization of a novel splice variant of human ZNF300 gene, which expressed highly in testis.". DNA Seq. 18 (4): 312–5. 2007. doi:10.1080/10425170701243393. PMID 17541838.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- Wellcome Trust Case Control Consortium; Clayton, David G.; Cardon, Lon R.; Craddock, Nick; Deloukas, Panos; Duncanson, Audrey; Kwiatkowski, Dominic P.; McCarthy, Mark I. et al. (2007). "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.". Nature 447 (7145): 661–78. doi:10.1038/nature05911. PMID 17554300. Bibcode: 2007Natur.447..661B.
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