Biology:TAL1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termed stem cell leukemia/T-cell acute leukemia 1 [i.e. SCL/TAL1]) is a protein that in humans is encoded by the TAL1 gene.[1][2]
The protein encoded by TAL1 is a basic helix-loop-helix transcription factor.
Interactions
TAL1 has been shown to interact with:
- CBFA2T3,[3]
- EP300,[4]
- GATA1,[3][5]
- LDB1,[3]
- LMO1,[6][7]
- LMO2,[3][5][6][7]
- SIN3A,[8]
- Sp1 transcription factor,[9] and
- TCF3.[3][10]
References
- ↑ "Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma". Proc Natl Acad Sci U S A 86 (13): 5039–43. August 1989. doi:10.1073/pnas.86.13.5039. PMID 2740341. Bibcode: 1989PNAS...86.5039F.
- ↑ "Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6886.
- ↑ 3.0 3.1 3.2 3.3 3.4 "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. 25 (2): 357–66. January 2006. doi:10.1038/sj.emboj.7600934. PMID 16407974.
- ↑ "p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein". Oncogene 18 (35): 4958–67. September 1999. doi:10.1038/sj.onc.1202889. PMID 10490830.
- ↑ 5.0 5.1 "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. October 1995. doi:10.1073/pnas.92.21.9585. PMID 7568177. Bibcode: 1995PNAS...92.9585O.
- ↑ 6.0 6.1 "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. August 1994. doi:10.1073/pnas.91.18.8617. PMID 8078932. Bibcode: 1994PNAS...91.8617V.
- ↑ 7.0 7.1 "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. October 1994. doi:10.1002/j.1460-2075.1994.tb06809.x. PMID 7957052.
- ↑ "mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor". Mol. Cell. Biol. 20 (6): 2248–59. March 2000. doi:10.1128/mcb.20.6.2248-2259.2000. PMID 10688671.
- ↑ "The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1". Blood 100 (7): 2430–40. October 2002. doi:10.1182/blood-2002-02-0568. PMID 12239153.
- ↑ "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. April 1994. doi:10.1073/pnas.91.8.3181. PMID 8159721. Bibcode: 1994PNAS...91.3181H.
Further reading
- "SCL and related hemopoietic helix-loop-helix transcription factors.". Int. J. Cell Cloning 10 (5): 269–76. 1993. doi:10.1002/stem.5530100504. PMID 1453013.
- "Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia.". Blood 79 (5): 1327–33. 1992. doi:10.1182/blood.V79.5.1327.1327. PMID 1311214.
- "The SCL gene product: a positive regulator of erythroid differentiation.". EMBO J. 11 (11): 4073–81. 1992. doi:10.1002/j.1460-2075.1992.tb05500.x. PMID 1396592.
- "T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein.". Blood 80 (11): 2858–66. 1992. doi:10.1182/blood.V80.11.2858.bloodjournal80112858. PMID 1450410.
- "Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene.". Oncogene 6 (8): 1477–88. 1991. PMID 1886719.
- "Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias.". Genes Chromosomes Cancer 1 (3): 194–208. 1991. doi:10.1002/gcc.2870010303. PMID 1964581.
- "Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.". J. Exp. Med. 172 (5): 1403–8. 1990. doi:10.1084/jem.172.5.1403. PMID 2230650.
- "The SCL gene is formed from a transcriptionally complex locus.". Mol. Cell. Biol. 10 (12): 6426–35. 1991. doi:10.1128/mcb.10.12.6426. PMID 2247063.
- "The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.". EMBO J. 9 (2): 415–24. 1990. doi:10.1002/j.1460-2075.1990.tb08126.x. PMID 2303035.
- "The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif.". Proc. Natl. Acad. Sci. U.S.A. 86 (24): 10128–32. 1990. doi:10.1073/pnas.86.24.10128. PMID 2602361.
- "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1.". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. 1995. doi:10.1073/pnas.92.21.9585. PMID 7568177. Bibcode: 1995PNAS...92.9585O.
- "Expression of TAL-1 proteins in human tissues.". Blood 85 (3): 675–84. 1995. doi:10.1182/blood.V85.3.675.bloodjournal853675. PMID 7833471.
- "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.". EMBO J. 13 (20): 4831–9. 1994. doi:10.1002/j.1460-2075.1994.tb06809.x. PMID 7957052.
- "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells.". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. 1994. doi:10.1073/pnas.91.18.8617. PMID 8078932. Bibcode: 1994PNAS...91.8617V.
- "Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line.". Oncogene 9 (10): 3013–6. 1994. PMID 8084606.
- "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells.". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. 1994. doi:10.1073/pnas.91.8.3181. PMID 8159721. Bibcode: 1994PNAS...91.3181H.
- "Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen.". Oncogene 8 (11): 3043–6. 1993. PMID 8414504.
- "Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1.". Mol. Cell. Biol. 13 (2): 801–8. 1993. doi:10.1128/mcb.13.2.801. PMID 8423803.
External links
- TAL1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- FactorBook TAL1
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