Biology:Homeobox protein SIX1
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Short description: Protein-coding gene in humans
 Generic protein structure example |
Homeobox protein SIX1 (Sine oculis homeobox homolog 1) is a protein that in humans is encoded by the SIX1 gene.[1][2][3]
Function
The vertebrate SIX genes are homologs of the Drosophila 'sine oculis' (so) gene, which is expressed primarily in the developing visual system of the fly. Members of the SIX gene family encode proteins that are characterized by a divergent DNA-binding homeodomain and an upstream SIX domain, which may be involved both in determining DNA-binding specificity and in mediating protein–protein interactions. Genes in the SIX family have been shown to play roles in vertebrate and insect development or have been implicated in maintenance of the differentiated state of tissues.[supplied by OMIM][3]
Interactions
SIX1 has been shown to interact with EYA1,[4] DACH, GRO and MDFI.[5]
References
- ↑ "Cloning of the human SIX1 gene and its assignment to chromosome 14". Genomics 33 (1): 140–2. April 1996. doi:10.1006/geno.1996.0172. PMID 8617500.
- ↑ "SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes". Proceedings of the National Academy of Sciences of the United States of America 101 (21): 8090–5. May 2004. doi:10.1073/pnas.0308475101. PMID 15141091. Bibcode: 2004PNAS..101.8090R.
- ↑ 3.0 3.1 "Entrez Gene: SIX1 sine oculis homeobox homolog 1 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6495.
- ↑ "Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome". Human Molecular Genetics 10 (24): 2775–81. November 2001. doi:10.1093/hmg/10.24.2775. PMID 11734542.
- ↑ "Towards a proteome-scale map of the human protein–protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
Further reading
- "Homeobox genes and connective tissue patterning". Development 121 (3): 693–705. March 1995. doi:10.1242/dev.121.3.693. PMID 7720577.
- "The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes". Oncogene 35 (27): 3485–3494. 2015. doi:10.1038/onc.2015.408. PMID 26500063.
- "Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: a possible mechanism of breast carcinogenesis". Proceedings of the National Academy of Sciences of the United States of America 95 (21): 12608–13. October 1998. doi:10.1073/pnas.95.21.12608. PMID 9770533. Bibcode: 1998PNAS...9512608F.
- "A novel locus (DFNA23) for prelingual autosomal dominant nonsyndromic hearing loss maps to 14q21-q22 in a Swiss German kindred". American Journal of Human Genetics 66 (6): 1984–8. June 2000. doi:10.1086/302931. PMID 10777717.
- "Cell cycle-regulated phosphorylation of the human SIX1 homeodomain protein". The Journal of Biological Chemistry 275 (29): 22245–54. July 2000. doi:10.1074/jbc.M002446200. PMID 10801845.
- "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". The Journal of Biological Chemistry 275 (41): 32129–34. October 2000. doi:10.1074/jbc.M004577200. PMID 10906137.
- "Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome". Human Molecular Genetics 10 (24): 2775–81. November 2001. doi:10.1093/hmg/10.24.2775. PMID 11734542.
- "Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition". The American Journal of Pathology 160 (6): 2181–90. June 2002. doi:10.1016/S0002-9440(10)61166-2. PMID 12057921.
- "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein". Molecular and Cellular Biology 22 (19): 6759–66. October 2002. doi:10.1128/MCB.22.19.6759-6766.2002. PMID 12215533.
- "Six3 and Six6 activity is modulated by members of the groucho family". Development 130 (1): 185–95. January 2003. doi:10.1242/dev.00185. PMID 12441302.
- "A gene locus for branchio-otic syndrome maps to chromosome 14q21.3-q24.3". Journal of Medical Genetics 40 (7): 515–9. July 2003. doi:10.1136/jmg.40.7.515. PMID 12843324.
- "The role of Six1 in mammalian auditory system development". Development 130 (17): 3989–4000. September 2003. doi:10.1242/dev.00628. PMID 12874121.
- "Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis". Nature 426 (6964): 247–54. November 2003. doi:10.1038/nature02083. PMID 14628042. Bibcode: 2003Natur.426..247L.
- "The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1". Proceedings of the National Academy of Sciences of the United States of America 101 (17): 6478–83. April 2004. doi:10.1073/pnas.0401139101. PMID 15123840. Bibcode: 2004PNAS..101.6478C.
- "Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype". Molecular and Cellular Biology 24 (14): 6253–67. July 2004. doi:10.1128/MCB.24.14.6253-6267.2004. PMID 15226428.
- "Towards a proteome-scale map of the human protein–protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "SIX1 mutation associated with enlargement of the vestibular aqueduct in a patient with branchio-oto syndrome". The Laryngoscope 116 (5): 796–9. May 2006. doi:10.1097/01.mlg.0000209096.40400.96. PMID 16652090.
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