Biology:Homeobox protein SIX1

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Short description: Protein-coding gene in humans


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Homeobox protein SIX1 (Sine oculis homeobox homolog 1) is a protein that in humans is encoded by the SIX1 gene.[1][2][3]

Function

The vertebrate SIX genes are homologs of the Drosophila 'sine oculis' (so) gene, which is expressed primarily in the developing visual system of the fly. Members of the SIX gene family encode proteins that are characterized by a divergent DNA-binding homeodomain and an upstream SIX domain, which may be involved both in determining DNA-binding specificity and in mediating protein–protein interactions. Genes in the SIX family have been shown to play roles in vertebrate and insect development or have been implicated in maintenance of the differentiated state of tissues.[supplied by OMIM][3]

Interactions

SIX1 has been shown to interact with EYA1,[4] DACH, GRO and MDFI.[5]

References

  1. "Cloning of the human SIX1 gene and its assignment to chromosome 14". Genomics 33 (1): 140–2. April 1996. doi:10.1006/geno.1996.0172. PMID 8617500. 
  2. "SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes". Proceedings of the National Academy of Sciences of the United States of America 101 (21): 8090–5. May 2004. doi:10.1073/pnas.0308475101. PMID 15141091. Bibcode2004PNAS..101.8090R. 
  3. 3.0 3.1 "Entrez Gene: SIX1 sine oculis homeobox homolog 1 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6495. 
  4. "Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome". Human Molecular Genetics 10 (24): 2775–81. November 2001. doi:10.1093/hmg/10.24.2775. PMID 11734542. 
  5. "Towards a proteome-scale map of the human protein–protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode2005Natur.437.1173R. 

Further reading