Biology:YY1
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Short description: Transcriptional repressor protein
 Generic protein structure example |
YY1 (Yin Yang 1)[1] is a transcriptional repressor protein in humans that is encoded by the YY1 gene.[2][3]
Function
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. Hence, the YY in the name stands for "yin-yang." YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.[4] YY1 promotes enhancer-promoter chromatin loops by forming dimers and promoting DNA interactions. Its dysregulation disrupts enhancer-promoter loops and gene expression.[5][6]
Clinical significance
YY1 heterozygous deletions, missense, and nonsense mutations cause Gabriele-DeVries syndrome (GADEVS),[7][8] an autosomal dominant neurodevelopmental disorder characterized by intellectual disability, dysmorphic facial features, feeding problems, intrauterine growth restriction, variable cognitive impairment, behavioral problems and other congenital malformations.[6] A website is available in order to collect and share clinical information between clinicians and the families of affected individuals.[9]
Interactions
YY1 has been shown to interact with:
- ATF6,[10]
- EP300[11][12]
- FKBP3[13]
- HDAC3[11][14]
- Histone deacetylase 2[11][14][15]
- Myc[16]
- NOTCH1[17]
- RYBP[18] and
- SAP30[19]
- Serine—tRNA ligase[20]
References
- ↑ "Oncogenic potential of yin yang 1 mediated through control of imprinted genes". Critical Reviews in Oncogenesis 16 (3–4): 199–209. 2011. doi:10.1615/critrevoncog.v16.i3-4.40. PMID 22248054.
- ↑ "Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein". Cell 67 (2): 377–88. Oct 1991. doi:10.1016/0092-8674(91)90189-6. PMID 1655281.
- ↑ "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mammalian Genome 5 (4): 234–6. Apr 1994. doi:10.1007/BF00360552. PMID 7912122.
- ↑ "Entrez Gene: YY1 YY1 transcription factor". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7528.
- ↑ "YY1 Is a Structural Regulator of Enhancer-Promoter Loops". Cell 171 (7): 1573–1588.e28. December 2017. doi:10.1016/j.cell.2017.11.008. PMID 29224777.
- ↑ 6.0 6.1 "YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction". American Journal of Human Genetics 100 (6): 907–925. June 2017. doi:10.1016/j.ajhg.2017.05.006. PMID 28575647.
- ↑ "OMIM:GABRIELE-DE VRIES SYNDROME". https://www.omim.org/entry/617557.
- ↑ Nabais Sá, M. J.; Gabriele, M.; Testa, G.; de Vries BBA; Adam, M. P.; Ardinger, H. H.; Pagon, R. A.; Wallace, S. E. et al. (1993). Gabriele-de Vries Syndrome. PMID 31145572.
- ↑ "YY1 – Collect information about clinic management and research projects". http://humandiseasegenes.nl/yy1/.
- ↑ "ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1". Molecular and Cellular Biology 20 (14): 5096–106. Jul 2000. doi:10.1128/mcb.20.14.5096-5106.2000. PMID 10866666.
- ↑ 11.0 11.1 11.2 "Regulation of transcription factor YY1 by acetylation and deacetylation". Molecular and Cellular Biology 21 (17): 5979–91. Sep 2001. doi:10.1128/mcb.21.17.5979-5991.2001. PMID 11486036.
- ↑ "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes & Development 9 (10): 1188–98. May 1995. doi:10.1101/gad.9.10.1188. PMID 7758944.
- ↑ "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". The EMBO Journal 20 (17): 4814–25. Sep 2001. doi:10.1093/emboj/20.17.4814. PMID 11532945.
- ↑ 14.0 14.1 "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". The Journal of Biological Chemistry 272 (44): 28001–7. Oct 1997. doi:10.1074/jbc.272.44.28001. PMID 9346952.
- ↑ "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Research 25 (4): 843–9. Feb 1997. doi:10.1093/nar/25.4.843. PMID 9016636.
- ↑ "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science 262 (5141): 1889–92. Dec 1993. doi:10.1126/science.8266081. PMID 8266081. Bibcode: 1993Sci...262.1889S.
- ↑ "Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch". The Journal of Biological Chemistry 278 (43): 41963–9. Oct 2003. doi:10.1074/jbc.M304353200. PMID 12913000.
- ↑ "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". The EMBO Journal 18 (12): 3404–18. Jun 1999. doi:10.1093/emboj/18.12.3404. PMID 10369680.
- ↑ "Modulation of YY1 activity by SAP30". Biochemical and Biophysical Research Communications 306 (1): 267–75. Jun 2003. doi:10.1016/s0006-291x(03)00966-5. PMID 12788099.
- ↑ "Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis". Nucleic Acids Research 45 (5): 2423–2437. Nov 2017. doi:10.1093/nar/gkw1187. PMID 27913726.
Further reading
- "Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?". Gene 236 (2): 197–208. Aug 1999. doi:10.1016/S0378-1119(99)00261-9. PMID 10452940.
- "Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site". Proceedings of the National Academy of Sciences of the United States of America 88 (21): 9804–8. Nov 1991. doi:10.1073/pnas.88.21.9804. PMID 1946405. Bibcode: 1991PNAS...88.9804P.
- "Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity". The Journal of Biological Chemistry 270 (25): 15187–93. Jun 1995. doi:10.1074/jbc.270.25.15187. PMID 7541038.
- "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes & Development 9 (10): 1188–98. May 1995. doi:10.1101/gad.9.10.1188. PMID 7758944.
- "Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB". Journal of Virology 69 (7): 4323–30. Jul 1995. doi:10.1128/JVI.69.7.4323-4330.1995. PMID 7769693.
- "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science 262 (5141): 1889–92. Dec 1993. doi:10.1126/science.8266081. PMID 8266081. Bibcode: 1993Sci...262.1889S.
- "Binding of the ubiquitous nuclear transcription factor YY1 to a cis regulatory sequence in the human LINE-1 transposable element". Human Molecular Genetics 2 (10): 1697–702. Oct 1993. doi:10.1093/hmg/2.10.1697. PMID 8268924. https://zenodo.org/record/1234317.
- "Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production". Journal of Virology 68 (2): 905–10. Feb 1994. doi:10.1128/JVI.68.2.905-910.1994. PMID 8289393.
- "Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1". Proceedings of the National Academy of Sciences of the United States of America 90 (13): 6145–9. Jul 1993. doi:10.1073/pnas.90.13.6145. PMID 8327494. Bibcode: 1993PNAS...90.6145L.
- "Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3". Proceedings of the National Academy of Sciences of the United States of America 93 (23): 12845–50. Nov 1996. doi:10.1073/pnas.93.23.12845. PMID 8917507. Bibcode: 1996PNAS...9312845Y.
- "Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator". Proceedings of the National Academy of Sciences of the United States of America 93 (24): 13577–82. Nov 1996. doi:10.1073/pnas.93.24.13577. PMID 8942976. Bibcode: 1996PNAS...9313577H.
- "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Research 25 (4): 843–9. Feb 1997. doi:10.1093/nar/25.4.843. PMID 9016636.
- "A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors". Nucleic Acids Research 25 (18): 3705–11. Sep 1997. doi:10.1093/nar/25.18.3705. PMID 9278494.
- "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". The Journal of Biological Chemistry 272 (44): 28001–7. Oct 1997. doi:10.1074/jbc.272.44.28001. PMID 9346952.
- "Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF". Journal of Virology 71 (12): 9375–82. Dec 1997. doi:10.1128/JVI.71.12.9375-9382.1997. PMID 9371597.
- "Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking". Journal of Cellular Biochemistry 68 (4): 500–10. Mar 1998. doi:10.1002/(SICI)1097-4644(19980315)68:4<500::AID-JCB9>3.0.CO;2-U. PMID 9493912.
- "Design, synthesis and structure of a zinc finger with an artificial beta-turn". Journal of Molecular Biology 279 (4): 973–86. Jun 1998. doi:10.1006/jmbi.1998.1764. PMID 9642075.
- "Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1". Nucleic Acids Research 26 (16): 3776–83. Aug 1998. doi:10.1093/nar/26.16.3776. PMID 9685495.
U== External links ==
- FactorBook YY1
- Overview of all the structural information available in the PDB for UniProt: P25490 (Transcriptional repressor protein YY1) at the PDBe-KB.
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