Biology:MNT (gene)
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
MNT (Max-binding protein MNT) is a Max-binding protein that is encoded by the MNT gene[1][2][3]
Function
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. Its delta signature is 44. This protein is a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA and recruiting Sin3 corepressor proteins through its N-terminal Sin3-interaction domain [1][4]
Interactions
MNT (gene) has been shown to interact with MLX,[5][6] SIN3A[7] and MAX.[7]
References
- ↑ 1.0 1.1 Hurlin, Peter; Queva, Christoph; Eisenman, Robert (January 1, 1997). "Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites". Genes & Development 11 (1): 44–58. doi:10.1101/gad.11.1.44. PMID 9000049.
- ↑ "The human ROX gene: genomic structure and mutation analysis in human breast tumors". Genomics 49 (2): 275–82. Apr 1998. doi:10.1006/geno.1998.5241. PMID 9598315.
- ↑ "Entrez Gene: MNT MAX binding protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4335.
- ↑ Merroni, G; Reymond, A; Alcalay, M; Borsani, G; Tanigami, A; Tonlorenzi, R; Lo Nigro, C; Messali, S et al. (May 15, 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor.". EMBO J 16 (10): 2892–2906. doi:10.1093/emboj/16.10.2892. PMID 9184233.
- ↑ "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics 10 (6): 617–27. Mar 2001. doi:10.1093/hmg/10.6.617. PMID 11230181.
- ↑ "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene 19 (29): 3266–77. Jul 2000. doi:10.1038/sj.onc.1203634. PMID 10918583.
- ↑ 7.0 7.1 "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". The EMBO Journal 16 (10): 2892–906. May 1997. doi:10.1093/emboj/16.10.2892. PMID 9184233.
Further reading
- "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". The EMBO Journal 16 (10): 2892–906. May 1997. doi:10.1093/emboj/16.10.2892. PMID 9184233.
- "Genomic organization of the murine Miller-Dieker/lissencephaly region: conservation of linkage with the human region". Genome Research 7 (6): 625–34. Jun 1997. doi:10.1101/gr.7.6.625. PMID 9199935.
- "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene 19 (29): 3266–77. Jul 2000. doi:10.1038/sj.onc.1203634. PMID 10918583.
- "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics 10 (6): 617–27. Mar 2001. doi:10.1093/hmg/10.6.617. PMID 11230181.
- "An internal ribosome entry segment in the 5' untranslated region of the mnt gene". Oncogene 20 (7): 893–7. Feb 2001. doi:10.1038/sj.onc.1204157. PMID 11314024.
- "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". The Journal of Biological Chemistry 277 (9): 7021–8. Mar 2002. doi:10.1074/jbc.M108417200. PMID 11748221.
- "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology 22 (6): 707–16. Jun 2004. doi:10.1038/nbt971. PMID 15146197.
- "Expression and DNA-binding activity of MYCN/Max and Mnt/Max during induced differentiation of human neuroblastoma cells". Journal of Cellular Biochemistry 92 (6): 1282–95. Aug 2004. doi:10.1002/jcb.20121. PMID 15258910.
- "Transcriptome analysis of human gastric cancer". Mammalian Genome 16 (12): 942–54. Dec 2005. doi:10.1007/s00335-005-0075-2. PMID 16341674.
- "Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia". Leukemia & Lymphoma 48 (6): 1200–7. Jun 2007. doi:10.1080/10428190701342018. PMID 17577784.
External links
- MNT+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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