Biology:RAR-related orphan receptor beta

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans is encoded by the RORB gene.[1]

Function

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside-diphosphate kinase involved in organogenesis and differentiation.[2]

In the brain, ROR-beta is concentrated in layer 4 of the cerebral cortex, where it plays a role in the development of structures such as barrel columns.[3]

A mutation in this gene also results in the loss of spinal cord interneurons and of saltatorial locomotion,[4] a type of hopping gait that in mammals can be found in rabbits, hares, kangaroos, and some species of rodents.

Interactions

RAR-related orphan receptor beta has been shown to interact with NME1.[5]

See also

References

  1. "Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors". Genes Dev. 8 (5): 538–53. March 1994. doi:10.1101/gad.8.5.538. PMID 7926749. 
  2. "Entrez Gene: RORB RAR-related orphan receptor B". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6096. 
  3. "RORβ induces barrel-like neuronal clusters in the developing neocortex". Cereb. Cortex 22 (5): 996–1006. May 2012. doi:10.1093/cercor/bhr182. PMID 21799210. 
  4. Carneiro, Miguel; Vieillard, Jennifer; Andrade, Pedro; Boucher, Samuel; Afonso, Sandra; Blanco-Aguiar, José A.; Santos, Nuno; Branco, João et al. (2021). "A loss-of-function mutation in RORB disrupts saltatorial locomotion in rabbits". PLOS Genetics 17 (3): e1009429. doi:10.1371/journal.pgen.1009429. PMID 33764968. 
  5. "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. October 1996. doi:10.1006/bbrc.1996.1471. PMID 8858107. 

Further reading

External links

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