Biology:Core binding factor

Short description: Type of transcription factor

The Core binding factor (CBF) is a group of heterodimeric transcription factors.

Core binding factors are composed of:

• a non-DNA-binding CBFβ chain (CBFB)
• a DNA-binding CBFα chain (RUNX1, RUNX2, RUNX3)

References

• "Core-binding factors in hematopoiesis and immune function". Oncogene 23 (24): 4238–48. 2004. doi:10.1038/sj.onc.1207763. PMID 15156179. 

See also

• AI-10-49, an anti-leukemic drug under development.

External links

• Core+Binding+Factors at the US National Library of Medicine Medical Subject Headings (MeSH)