Biology:GATA5
Transcription factor GATA-5 is a protein that in humans is encoded by the GATA5 gene.[1][2]
Function
The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity.[2]
Role in development
Gata5 is a transcription factor. Gata5 regulates the proper development of the heart. Early in embryo development, Gata5 helps in making sure that there are enough heart muscle precursor cells produced to differentiate into the final myocardial cells. It also regulates other genes that are crucial to successful heart development.[3] As pregnancy progresses, Gata 5 is involved in the specification of the heart tissue that becomes the ventricles. Problems can arise when Gata5 is overexpressed. This overexpression can lead to ectopic foci. Ectopic foci are also known as ectopic pacemakers. They are bundles of cells that can cause cardiac pacing that are located in places in the heart where they're not supposed to be. These cells can become excited before the heart is supposed to be excited. This causes the heart to beat and thus contract before it should. Oftentimes, this is not a big deal and the heart naturally reverts to its normal pacing. However, if it's caused by problems with development in the heart – if Gata5 did not express properly in the embryo- then this can lead to constant ectopic foci problems. These problems include tachycardia (the heart beating too fast), bradycardia (the heart beating too slow), or ventricular fibrillation[4] which is a serious condition where the ventricles of the heart aren't pumping consistently and can't get blood out to the body.
See also
References
- ↑ "Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation". Molecular and Cellular Biology 18 (5): 2901–11. May 1998. doi:10.1128/mcb.18.5.2901. PMID 9566909.
- ↑ Jump up to: 2.0 2.1 "Entrez Gene: GATA5 GATA binding protein 5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=140628.
- ↑ "Gata5 is required for the development of the heart and endoderm in zebrafish" (in en). Genes & Development 13 (22): 2983–95. November 1999. doi:10.1101/gad.13.22.2983. PMID 10580005.
- ↑ "Ventricular fibrillation". Mayo Clinic. http://www.mayoclinic.org/diseases-conditions/ventricular-fibrillation/basics/definition/con-20034473.
Further reading
- "p300 protein as a coactivator of GATA-5 in the transcription of cardiac-restricted atrial natriuretic factor gene". The Journal of Biological Chemistry 274 (48): 34096–102. November 1999. doi:10.1074/jbc.274.48.34096. PMID 10567378.
- "Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha". American Journal of Physiology. Gastrointestinal and Liver Physiology 281 (1): G69–84. July 2001. doi:10.1152/ajpgi.2001.281.1.g69. PMID 11408257.
- "Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter". The Journal of Biological Chemistry 277 (31): 27659–67. August 2002. doi:10.1074/jbc.M203645200. PMID 12011060.
- "GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations". Molecular and Cellular Biology 23 (18): 6646–61. September 2003. doi:10.1128/MCB.23.18.6646-6661.2003. PMID 12944489.
- "GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer". Molecular and Cellular Biology 23 (23): 8429–39. December 2003. doi:10.1128/MCB.23.23.8429-8439.2003. PMID 14612389.
- "GATA-4, GATA-5, and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1alpha". American Journal of Physiology. Gastrointestinal and Liver Physiology 287 (5): G1086–99. November 2004. doi:10.1152/ajpgi.00421.2003. PMID 14715527.
- "Hypermethylation of the GATA genes in lung cancer". Clinical Cancer Research 10 (23): 7917–24. December 2004. doi:10.1158/1078-0432.CCR-04-1140. PMID 15585625.
- "Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis". Cancer Letters 241 (2): 281–8. September 2006. doi:10.1016/j.canlet.2005.10.039. PMID 16337738.
- "Hypermethylation of the GATA gene family in esophageal cancer". International Journal of Cancer 119 (9): 2078–83. November 2006. doi:10.1002/ijc.22092. PMID 16823849.
External links
- GATA5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
![]() | Original source: https://en.wikipedia.org/wiki/GATA5.
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