Biology:KLF13
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.[1][2][3]
There is some evidence for KLF13 having a role in obesity. A methylation site, cg07814318, within the first intron of KLF13 has been associated with obesity and orexigenic processes.[4] Ghrelin levels also positively correlated with methylation levels of cg07814318.[4] Moreover, expression levels of KLF13 were decreased and increased in the brains of starved and obese mice, respectively.[4]
Function
KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.[1][5]
KLF13 was first described as the RANTES factor of late activated T lymphocytes (RFLAT)-1.[3] It regulates the expression of the chemokine RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of Bcl-xL expression.[3][6][7][8][9][10][11]
Interactions
KLF13 has been shown to interact with CREB-binding protein,[12] Heat shock protein 47[12] and PCAF.[12]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: KLF13 Kruppel-like factor 13". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51621.
- ↑ "Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors". Annals of the New York Academy of Sciences 880 (1 CELL AND MOLE): 94–102. Jun 1999. doi:10.1111/j.1749-6632.1999.tb09513.x. PMID 10415854. Bibcode: 1999NYASA.880...94C.
- ↑ 3.0 3.1 3.2 "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes". Immunity 10 (1): 93–103. Jan 1999. doi:10.1016/S1074-7613(00)80010-2. PMID 10023774.
- ↑ 4.0 4.1 4.2 "A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels.". Int J Obes (Lond) 43 (6): 990–994. 14 Feb 2017. doi:10.1038/ijo.2017.43. PMID 28194012.
- ↑ "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family". Genomics 70 (1): 93–101. Nov 2000. doi:10.1006/geno.2000.6362. PMID 11087666.
- ↑ "Transcriptional regulation of RANTES expression in T lymphocytes". Immunological Reviews 177 (1): 236–45. Oct 2000. doi:10.1034/j.1600-065X.2000.17610.x. PMID 11138780.
- ↑ "A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes". The Journal of Clinical Investigation 110 (1): 119–26. Jul 2002. doi:10.1172/JCI15336. PMID 12093895.
- ↑ "Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes". The Journal of Biological Chemistry 277 (33): 30055–65. Aug 2002. doi:10.1074/jbc.M204278200. PMID 12050170.
- ↑ "Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo". Journal of Immunology 178 (9): 5496–504. May 2007. doi:10.4049/jimmunol.178.9.5496. PMID 17442931.
- ↑ "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription". Journal of Immunology 178 (11): 7081–7. Jun 2007. doi:10.4049/jimmunol.178.11.7081. PMID 17513757.
- ↑ "Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes". Molecular and Cellular Biology 27 (1): 253–66. Jan 2007. doi:10.1128/MCB.01071-06. PMID 17074812.
- ↑ 12.0 12.1 12.2 "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2". The Journal of Biological Chemistry 277 (9): 7029–36. Mar 2002. doi:10.1074/jbc.M108826200. PMID 11748222.
Further reading
- "Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors". Annals of the New York Academy of Sciences 880 (1 CELL AND MOLE): 94–102. Jun 1999. doi:10.1111/j.1749-6632.1999.tb09513.x. PMID 10415854. Bibcode: 1999NYASA.880...94C.
- "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes". Immunity 10 (1): 93–103. Jan 1999. doi:10.1016/S1074-7613(00)80010-2. PMID 10023774.
- "FKLF-2: a novel Krüppel-like transcriptional factor that activates globin and other erythroid lineage genes". Blood 95 (11): 3578–84. Jun 2000. doi:10.1182/blood.V95.11.3578. PMID 10828046.
- "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family". Genomics 70 (1): 93–101. Nov 2000. doi:10.1006/geno.2000.6362. PMID 11087666.
- "The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1". The Journal of Biological Chemistry 276 (39): 36749–56. Sep 2001. doi:10.1074/jbc.M105831200. PMID 11477107.
- "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2". The Journal of Biological Chemistry 277 (9): 7029–36. Mar 2002. doi:10.1074/jbc.M108826200. PMID 11748222.
- "Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter". The Biochemical Journal 366 (Pt 3): 873–82. Sep 2002. doi:10.1042/BJ20020388. PMID 12036432.
- "Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes". The Journal of Biological Chemistry 277 (33): 30055–65. Aug 2002. doi:10.1074/jbc.M204278200. PMID 12050170.
- "A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes". The Journal of Clinical Investigation 110 (1): 119–26. Jul 2002. doi:10.1172/JCI15336. PMID 12093895.
- "Transcriptional regulation of FKLF-2 (KLF13) gene in erythroid cells". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1727 (2): 125–33. Feb 2005. doi:10.1016/j.bbaexp.2004.12.007. PMID 15716005.
- "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element". Blood Cells, Molecules & Diseases 35 (2): 227–35. 2006. doi:10.1016/j.bcmd.2005.04.009. PMID 16023392.
- "Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes". Molecular and Cellular Biology 27 (1): 253–66. Jan 2007. doi:10.1128/MCB.01071-06. PMID 17074812.
- "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription". Journal of Immunology 178 (11): 7081–7. Jun 2007. doi:10.4049/jimmunol.178.11.7081. PMID 17513757.
External links
- KLF13+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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