Biology:NKX2-2
 Generic protein structure example |
Homeobox protein Nkx-2.2 is a protein that in humans is encoded by the NKX2-2 gene.[1][2][3]
Homeobox protein Nkx-2.2 contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.[3]
The expression of Nkx2-2 is regulated by an antisense RNA called Nkx2-2as.[4]
In the developing spinal cord, Nkx-2.2 regulates IRX3 thereby contributing to the proper differentiation of the ventral horn neurons.[5]
References
- ↑ "Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese". Diabetes 47 (8): 1356–1358. Aug 1998. doi:10.2337/diabetes.47.8.1356. PMID 9703340.
- ↑ "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron 8 (2): 241–255. Feb 1992. doi:10.1016/0896-6273(92)90291-K. PMID 1346742.
- ↑ 3.0 3.1 "Entrez Gene: NKX2-2 NK2 transcription factor related, locus 2 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4821.
- ↑ "Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation". Biochemical and Biophysical Research Communications 372 (4): 691–696. Aug 2008. doi:10.1016/j.bbrc.2008.05.127. PMID 18538132.
- ↑ "Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cord". PLOS ONE 9 (11): e111430. November 2014. doi:10.1371/journal.pone.0111430. PMID 25398016. Bibcode: 2014PLoSO...9k1430L.
Further reading
- "The homeodomain of Nkx2.2 carries two cooperatively acting nuclear localization signals". Biochemical and Biophysical Research Communications 270 (3): 695–700. Apr 2000. doi:10.1006/bbrc.2000.2491. PMID 10772886.
- "Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals". Mammalian Genome 11 (6): 466–468. Jun 2000. doi:10.1007/s003350010089. PMID 10818213.
- "Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex". The Journal of Neuroscience 23 (29): 9547–9556. Oct 2003. doi:10.1523/JNEUROSCI.23-29-09547.2003. PMID 14573534.
- "Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma". Cancer Cell 9 (5): 405–416. May 2006. doi:10.1016/j.ccr.2006.04.004. PMID 16697960.
- "Function and regulation of zebrafish nkx2.2a during development of pancreatic islet and ducts". Developmental Biology 304 (2): 875–890. Apr 2007. doi:10.1016/j.ydbio.2007.01.024. PMID 17335795.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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